Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

BACKGROUND: Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown. OBJECTIVE: The objective was to examine the effec...

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Bibliographic Details
Published in:	The American journal of clinical nutrition 2009-08, Vol.90 (2), p.415-424
Main Authors:	Bouwens, Mark, van de Rest, Ondine, Dellschaft, Neele, Bromhaar, Mechteld Grootte, de Groot, Lisette CPGM, Geleijnse, Johanna M, Müller, Michael, Afman, Lydia A
Format:	Article
Language:	English
Subjects:	activated receptor-alpha administration & dosage Aged Aged, 80 and over analysis anti-inflammatory agents antiatherogenic status Biological and medical sciences Blood blood cells Cells controlled-trial cytokine production Dietary Supplements disease prevention DNA, Complementary DNA, Complementary - analysis docosahexaenoic acid Docosahexaenoic Acids Docosahexaenoic Acids - administration & dosage dose response Dose-Response Relationship, Drug Double-Blind Method drug effects eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage elderly Fatty acids Fatty Acids, Omega-3 Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Unsaturated Fatty Acids, Unsaturated - administration & dosage Feeding. Feeding behavior Female Fish oils Fish Oils - administration & dosage Fish Oils - pharmacology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling gene expression regulation Genes Helianthus human diseases Humans Hypoxia Immune system inflammation Inflammation - prevention & control Leukocytes, Mononuclear Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male men metabolism Microarray Analysis murine macrophages n-3 Netherlands nitric-oxide nutrigenomics Nutrition oxidative stress peripheral blook mononuclear cells pharmacology Polymerase Chain Reaction Polyunsaturated fatty acids prevention & control RNA RNA - analysis Sunflower oil transcriptional activation Vertebrates: anatomy and physiology, studies on body, several organs or systems women
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