Percutaneous Coronary Interventions Affect Concentrations of Interleukin 6 and Its Soluble Receptors in Coronary Sinus Blood in Patients with Stable Angina

Coronary stenting may create local inflammatory reaction. Interleukin 6 effects depend on the presence of soluble receptors (sIL-6R and sgp130) that facilitate or impede interleukin 6 signal transduction. Concentrations of interleukin 6 and its soluble receptors were assessed in aorta and coronary s...

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Bibliographic Details
Published in:Angiology 2009-06, Vol.60 (3), p.322-328
Main Authors: Kamiński, Karol A., Kozieradzka, Anna, Bonda, Tomasz, Banach, Maciej, Kozuch, Marcin, Wojtkowska, Izabela, Dobrzycki, Slawomir, Kralisz, Paweł, Nowak, Konrad, Prokopczuk, Przemysław, Mikhailidis, Dimitri P., Musial, Wlodzimierz J.
Format: Article
Language:English
Subjects:
Aged
Angina Pectoris - immunology
Angina Pectoris - therapy
Angioplasty, Balloon, Coronary
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Coronary heart disease
Coronary Sinus
Cytokine Receptor gp130 - blood
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Heart
Humans
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Myocardial Ischemia - immunology
Myocardial Ischemia - therapy
Reference Values
Signal Transduction - physiology
Stents
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Summary:Coronary stenting may create local inflammatory reaction. Interleukin 6 effects depend on the presence of soluble receptors (sIL-6R and sgp130) that facilitate or impede interleukin 6 signal transduction. Concentrations of interleukin 6 and its soluble receptors were assessed in aorta and coronary sinus after stenting in optimally treated stable angina patients scheduled for elective stenting. Baseline levels of interleukin 6 and its soluble receptors in patients did not differ from healthy controls. Initial levels of sIL-6R in aorta were significantly higher than in coronary sinus but this difference disappeared after intervention. Stenting caused interleukin 6 concentration increase to a similar extent both in coronary sinus and in aorta. Moreover, there was significantly higher sgp130 concentration in coronary sinus than in aorta. Coronary intervention increases concentration of interleukin 6 in patients with stable angina. It affects the cardiac level of interleukin 6 soluble receptors what may influence the local inflammatory reaction.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319708330008