Occult hepatitis B virus infection in a North American community-based population

Occult hepatitis B virus (HBV) infection [HBV-DNA detection in hepatitis B surface antigen (HBsAg)-negative individuals] may cause acute and/or chronic liver disease. The objective of this study was to document the prevalence of occult HBV in an isolated, North American Inuit community. Four hundred...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepatology 2005-04, Vol.42 (4), p.480-485
Main Authors: Minuk, Gerald Y., Sun, Dong-feng, Uhanova, Julia, Zhang, Manna, Caouette, Shauna, Nicolle, Lindsay E., Gutkin, Adam, Doucette, Karen, Martin, Bruce, Giulivi, Antonio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Biological and medical sciences
Canada - epidemiology
Child
Child, Preschool
DNA, Viral - blood
Epidemiology
Female
HBV-DNA
Hepatitis
Hepatitis B
Hepatitis B Surface Antigens - genetics
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - ethnology
Human viral diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Inuits - statistics & numerical data
Liver disease
Male
Medical sciences
Middle Aged
Occult hepatitis B
Prevalence
S-mutant
Sex Distribution
Viral diseases
Viral diseases of the digestive system
Viral hepatitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Occult hepatitis B virus (HBV) infection [HBV-DNA detection in hepatitis B surface antigen (HBsAg)-negative individuals] may cause acute and/or chronic liver disease. The objective of this study was to document the prevalence of occult HBV in an isolated, North American Inuit community. Four hundred and eighty seven HBsAg negative sera (61% of the community population) were available for HBV-DNA testing by real time PCR. Of these, 80 (Group 1) had serologic evidence of resolved HBV infection and 407 (Group 2) were HBV-seronegative. HBV-DNA was detected in 14/80 (18%) and S-variants in 12/14 (86%) samples from Group 1. In Group 2, HBV-DNA was detected in 33/407 (8.1%) and S-variants in 17/33 (52%). In all cases (Groups 1 and 2) viral loads were low (
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2004.11.037