Severity of cholestasis and advanced histological stage but not menopausal status are the major risk factors for osteoporosis in primary biliary cirrhosis

Since primary biliary cirrhosis (PBC) is usually diagnosed in postmenopausal women with minor cholestasis, it has been questioned whether PBC itself represents a further risk for osteoporosis. To assess the prevalence and risk factors for osteoporosis in an unselected series of women with PBC. 142 w...

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Bibliographic Details
Published in:Journal of hepatology 2005-04, Vol.42 (4), p.573-577
Main Authors: Guañabens, Núria, Parés, Albert, Ros, Inmaculada, Caballería, Llorenç, Pons, Francesca, Vidal, Sergi, Monegal, Ana, Peris, Pilar, Rodés, Juan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers
Body Mass Index
Bone Density
Bone fracture
Bone mineral density
Bone turnover
Cholestasis - epidemiology
Cholestasis - pathology
Diseases of the osteoarticular system
Female
Fractures, Bone - epidemiology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Cirrhosis, Biliary - epidemiology
Liver Cirrhosis, Biliary - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Mayo score
Medical sciences
Menopause
Middle Aged
Osteoporosis - epidemiology
Osteoporosis - pathology
Osteoporosis. Osteomalacia. Paget disease
Other diseases. Semiology
Prevalence
Risk Factors
Severity of Illness Index
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Summary:Since primary biliary cirrhosis (PBC) is usually diagnosed in postmenopausal women with minor cholestasis, it has been questioned whether PBC itself represents a further risk for osteoporosis. To assess the prevalence and risk factors for osteoporosis in an unselected series of women with PBC. 142 women with PBC (age: 54.3±0.8 years) and an age-matched control group. Osteoporosis was established by densitometry (bone mineral density below −2.5 T-score). Age, duration and severity of PBC, body mass index, menopausal status, histological stage and markers of bone turnover were assessed. Prevalence of osteoporosis was higher in PBC (32.4%) than in normal women (11. 1%) (RR: 3.83, 95%CI: 2.59–5.67, P
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2004.11.035