Neuroligand binding endophenotypes in blood cells distinguish two subsets of borderline personality disorder patients

Neurotransmitter ligand binding in blood cells was assessed in borderline personality disorder (BDP) patients, testing the possibility that different biochemical endophenotypes might lie beneath a specific clinical presentation. The density of peripheral benzodiazepine receptors (PBR) and serotonin...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2009-09, Vol.462 (2), p.144-146
Main Authors: Begni, Barbara, Tremolizzo, Lucio, Andreoni, Simona, Contri, Margherita, Uccellini, Orlando, Neri, Francesca, Ferrarese, Carlo
Format: Article
Language:English
Subjects:
Adolescent
Borderline personality disorder
Borderline Personality Disorder - blood
Childhood Depression Inventory
Hematologic Tests - methods
Humans
Leukocytes, Mononuclear - metabolism
Ligand binding
PBMC
Peripheral benzodiazepine receptors
Phenotype
Platelets
Receptors, GABA-A - blood
Serotonin - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurotransmitter ligand binding in blood cells was assessed in borderline personality disorder (BDP) patients, testing the possibility that different biochemical endophenotypes might lie beneath a specific clinical presentation. The density of peripheral benzodiazepine receptors (PBR) and serotonin transporters were assessed in peripheral blood mononuclear cells (PBMC) and platelets, respectively, showing a decrease of both parameters. Moreover, a further significant decrease of PBR in PBMC was shown for those patients with a depressive trait. Further confirmation of the presence of different molecular endophenotypes underlying the dissimilar clinical presentations in BPD may advance our possibility of successfully treating these patients.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2009.07.002