Connatal tuberculosis in a very premature infant

Connatal tuberculosis is increasing in incidence and the mortality and morbidity of this disease remains high. We report a 27-week-old, 896 g female premature infant who had mild respiratory distress syndrome after birth. She developed signs of infection, progressive pneumonia and atelectasis which...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pediatrics 2005-04, Vol.164 (4), p.244-247
Main Authors: CHANG, Mei-Ling, JOU, Shiann-Tarng, WANG, Chao-Ran, CHUNG, Ming-Tsung, LAI, Shen-Hao, WONG, Kin-Sun, HUANG, Yhu-Chering, CHOU, Yi-Hung
Format: Article
Language:English
Subjects:
Antitubercular Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
Female
General aspects
Human bacterial diseases
Humans
Infant, Newborn
Infant, Premature
Infectious diseases
Medical sciences
Radiography
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Miliary - congenital
Tuberculosis, Miliary - diagnostic imaging
Tuberculosis, Miliary - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Connatal tuberculosis is increasing in incidence and the mortality and morbidity of this disease remains high. We report a 27-week-old, 896 g female premature infant who had mild respiratory distress syndrome after birth. She developed signs of infection, progressive pneumonia and atelectasis which did not respond to mechanical ventilation and antibiotics. At 41 days of age, Mycobacterium tuberculosis was isolated from the non-bronchoscopic bronchoalveolar lavage. The isolate was sensitive to isoniazid, rifampin, streptomycin, and pyrazinamide. Miliary tuberculosis was subsequently diagnosed in her mother on a chest X-ray film and sputum cultures. The infant was treated successfully with anti-tuberculosis drugs. She had normal growth and development at the chronological age of 20 months old. Connatal tuberculosis should be considered in premature infants with symptoms of sepsis refractory to antibiotics. Most premature infants with connatal tuberculosis have lung involvement, and non-bronchoscopic bronchoalveolar lavage can be a useful procedure to establish the diagnosis.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-004-1600-0