Three-dimensional scaffold made from recombinant spider silk protein for tissue engineering

The natural polymers (biopolymers) and their derivatives alginates, collagen, gelatin, chitosan, hyaluronic acid, and polyesters of bacterial origin are now preferred as materials for reconstructive and substitutive medicine. Biopolymers are highly biocompatible and also can act as biostimulants. Af...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2009-06, Vol.426 (1), p.127-130
Main Authors: Agapov, I. I., Pustovalova, O. L., Moisenovich, M. M., Bogush, V. G., Sokolova, O. S., Sevastyanov, V. I., Debabov, V. G., Kirpichnikov, M. P.
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Arachnids
Araneae
Biochemistry
Biocompatible Materials
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Insect Proteins - chemistry
Life Sciences
Mice
Microscopy, Electron, Scanning
Molecular Biology
Polymers
Proteins
Recombinant Proteins - chemistry
Silk
Silk - chemistry
Spiders
Studies
Tissue Engineering
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Summary:The natural polymers (biopolymers) and their derivatives alginates, collagen, gelatin, chitosan, hyaluronic acid, and polyesters of bacterial origin are now preferred as materials for reconstructive and substitutive medicine. Biopolymers are highly biocompatible and also can act as biostimulants. After implantation they degrade to simpler compounds that are removed from the body or involved in cell metabolic processes. Impressive mechanical properties of spider silk attracted attention of scientists and have been extensively discussing for ten years. Viscoelastic fibers made of spider silk are highly elastic and resistant to rupture. Tensile strength of this material exceeds steel and is comparable with Kevlar. These characteristics of spider silk make this biopolymer a unique material among other natural and the majority of articial materials.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672909030016