Anti‐Saccharomyces cerevisiae and perinuclear anti‐neutrophil cytoplasmic antibodies in coeliac disease before and after gluten‐free diet

Summary Background : Anti‐Saccharomyces cerevisiae and perinuclear anti‐neutrophil cytoplasmic autoantibodies are markers of Crohn's disease and ulcerative colitis respectively. Aim : To determine the prevalence of anti‐S. cerevisiae and perinuclear anti‐neutrophil cytoplasmic autoantibodies in...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2005-04, Vol.21 (7), p.881-887
Main Authors: Granito, A., Zauli, D., Muratori, P., Muratori, L., Grassi, A., Bortolotti, R., Petrolini, N., Veronesi, L., Gionchetti, P., Bianchi, F. B., Volta, U.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Antineutrophil Cytoplasmic - blood
Antibodies, Fungal - blood
Biological and medical sciences
Celiac Disease - diet therapy
Celiac Disease - immunology
Digestive system
Enzyme-Linked Immunosorbent Assay - methods
Female
Fluorescent Antibody Technique, Direct - methods
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Saccharomyces cerevisiae - immunology
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Summary:Summary Background : Anti‐Saccharomyces cerevisiae and perinuclear anti‐neutrophil cytoplasmic autoantibodies are markers of Crohn's disease and ulcerative colitis respectively. Aim : To determine the prevalence of anti‐S. cerevisiae and perinuclear anti‐neutrophil cytoplasmic autoantibodies in a large series of coeliac disease patients before and after gluten free diet, and to correlate anti‐S. cerevisiae‐positivity with intestinal mucosal damage. Methods : One hundred and five consecutive coeliac disease patients and 141 controls (22 ulcerative colitis, 24 Crohn's disease, 30 primary sclerosing cholangitis, 15 postenteritis syndrome, 50 blood donors) were tested for anti‐S. cerevisiae by enzyme‐linked immunosorbent assay and for perinuclear anti‐neutrophil cytoplasmic autoantibodies by indirect immunofluorescence. Results : In coeliac disease anti‐S. cerevisiae (immunoglobulin G and/or immunoglobulin A) were slightly less frequent (59%) than in Crohn's disease (75%, P = 0.16) and significantly more frequent than in ulcerative colitis (27%), primary sclerosing cholangitis (30%), postenteritis syndrome (26%) and blood donors (4%) (P = 0.009, P = 0.0002, P = 0.025, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2005.02417.x