Obesity does not increase the risk of lymph node metastases in patients with clinically localized prostate cancer undergoing radical prostatectomy and extended pelvic lymph node dissection

Objectives:  Several studies have shown that obesity is associated with more aggressive prostate cancer (PCa) variants. We hypothesized that obesity, quantified as body mass index (BMI), is associated with a higher risk of lymph node invasion (LNI) in patients undergoing extended pelvic lymph node d...

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Bibliographic Details
Published in:International journal of urology 2009-08, Vol.16 (8), p.676-681
Main Authors: Briganti, Alberto, Karakiewicz, Pierre I, Chun, Felix K-H, Suardi, Nazareno, Gallina, Andrea, Abdollah, Firas, Freschi, Massimo, Doglioni, Claudio, Rigatti, Patrizio, Montorsi, Francesco
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
extended pelvic lymph node dissection
Humans
Lymph Node Excision - methods
lymph node invasion
Lymphatic Metastasis
Male
Middle Aged
obesity
Obesity - complications
Pelvis
prostate cancer
Prostatectomy - methods
Prostatic Neoplasms - complications
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Risk Factors
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Summary:Objectives:  Several studies have shown that obesity is associated with more aggressive prostate cancer (PCa) variants. We hypothesized that obesity, quantified as body mass index (BMI), is associated with a higher risk of lymph node invasion (LNI) in patients undergoing extended pelvic lymph node dissection (ePLND). Methods:  Clinical and pathological data were available for 994 consecutive men with PCa treated with radical prostatectomy (RP) and ePLND at a single European tertiary academic centre. Univariable and multivariable logistic regression analyses addressed the rate of LNI. Covariates consisted of pre‐treatment prostate specific antigen (PSA), biopsy Gleason sum, clinical stage history of diabetes mellitus as well as BMI coded as either continuous or categorized (
ISSN:0919-8172
1442-2042
DOI:10.1111/j.1442-2042.2009.02330.x