Autonomous innervation in renal inflammatory disease—innocent bystander or active modulator?

Increasing evidence suggests a significant interrelation between the autonomic nervous system and the immune system. The kidney is innervated by efferent sympathetic nerves as well as by peptidergic sensory afferent nerve fibers. Inflammation in the kidney may be affected by both types of fibers. Pe...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2009-09, Vol.87 (9), p.865-870
Main Authors: Ditting, Tilmann, Tiegs, Gisa, Veelken, Roland
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Human Genetics
Humans
Immune System - pathology
Inflammation - etiology
Internal Medicine
Kidney - immunology
Kidney - innervation
Kidney Diseases - etiology
Kidney Diseases - pathology
Kidney Diseases - physiopathology
Molecular Medicine
Review
Sclerosis - etiology
Sensory Receptor Cells
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Summary:Increasing evidence suggests a significant interrelation between the autonomic nervous system and the immune system. The kidney is innervated by efferent sympathetic nerves as well as by peptidergic sensory afferent nerve fibers. Inflammation in the kidney may be affected by both types of fibers. Peptidergic “sensory” neurons might play a particularly important role: These fibers can induce local neurogenic inflammation via paracrine effects of their transmitters and evoke increased efferent sympathetic nerve outflow via their projections to the central nervous system. Several reports support the notion that renal innervation does indeed contribute to inflammation and sclerosis in kidney diseases. Hence, receptor antagonists interfering with the interaction of innervation and the immune system may prove useful to mitigate inflammatory processes in the kidney.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-009-0498-4