GASTRIC SCHWANNOMA WITH ADJACENT EXTERNAL PROGRESSION HARBORED ABERRANT NF2 GENE

Gastric schwannomas are rare benign mesenchymal tumors. We describe a schwannoma of gastric origin with adjacent external progression. Sections showed a spindle cell tumor arranged in interlaced bundles and fascicles that was S‐100 and CD34 positive but c‐KIT protein negative. Histology and immunohi...

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Bibliographic Details
Published in:Digestive endoscopy 2009-07, Vol.21 (3), p.192-195
Main Authors: Ogasawara, Naotaka, Sasaki, Makoto, Ishiguro, Hideyuki, Itoh, Yukimi, Nojiri, Syunsuke, Kubota, Eiji, Wada, Tsuneya, Kataoka, Hiromi, Kuwabara, Yoshiyuki, Joh, Takashi
Format: Article
Language:English
Subjects:
Disease Progression
Female
gastric mutation
Humans
Middle Aged
Neurilemmoma - genetics
Neurilemmoma - surgery
neurofibromatosis 2
Neurofibromatosis 2 - genetics
schwannoma
Stomach Neoplasms - genetics
Stomach Neoplasms - surgery
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Summary:Gastric schwannomas are rare benign mesenchymal tumors. We describe a schwannoma of gastric origin with adjacent external progression. Sections showed a spindle cell tumor arranged in interlaced bundles and fascicles that was S‐100 and CD34 positive but c‐KIT protein negative. Histology and immunohistochemistry revealed the typical appearance of a gastric schwannoma. Genetic evaluation revealed that the tumor harbored a point mutation in exon 6 of the tumor suppressor neurofibromatosis 2 (NF2) gene, which resulted in an amino acid substitution of NF2 protein, and no mutation in exon 4b of the NF1 gene. In conclusion, we identified a rare mutation of the NF2 gene in gastric schwannoma. A diagnosis can only be definitive when based on histological and immunohistochemical findings. Digestive tract schwannomas are rare mesenchymal tumors that are differentiated from gastrointestinal stromal tumors by the absence of KIT protein. Follow up suggested that complete resection is an effective long‐term treatment strategy.
ISSN:0915-5635
1443-1661
DOI:10.1111/j.1443-1661.2009.00885.x