Outcome of multiple-wire localization for larger breast cancers: do multiple wires translate into additional imaging, biopsies, and recurrences?

Abstract Background Breast conservation is possible in breast cancer patients whose mammographic lesions are large enough to require multiple localizing wires for excision. Methods A retrospective review of 112 patients who underwent multiple-wire and 160 controls who underwent single-wire lumpectom...

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Bibliographic Details
Published in:The American journal of surgery 2009-09, Vol.198 (3), p.368-372
Main Authors: Javid, Sara H., M.D, Kirstein, Laurie J., M.D, Rafferty, Elizabeth, M.D, Lipsitz, Stuart, ScD, Moore, Richard, AB, Rusby, Jennifer E., M.D, Murphy, Colleen D., M.D, Hughes, Kevin S., M.D, Specht, Michelle C., M.D, Taghian, Alphonse G., M.D., Ph.D, Smith, Barbara L., M.D., Ph.D
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - surgery
Breasts
Cancer
Female
General aspects
Gynecology. Andrology. Obstetrics
Humans
Imaging
Lesions
Local recurrence
Localization
Lumpectomy
Mammary gland diseases
Mammography
Mastectomy
Mastectomy, Segmental - instrumentation
Mastectomy, Segmental - methods
Medical sciences
Metastases
Middle Aged
Multiple wire localization
Neoplasm Metastasis
Neoplasm Recurrence, Local
Patients
Radiography
Retrospective Studies
Surgery
Treatment Outcome
Tumors
Wire
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Summary:Abstract Background Breast conservation is possible in breast cancer patients whose mammographic lesions are large enough to require multiple localizing wires for excision. Methods A retrospective review of 112 patients who underwent multiple-wire and 160 controls who underwent single-wire lumpectomy for breast cancer. Rates of in-breast recurrence, metastasis, and additional imaging and biopsy procedures were calculated. Results The median follow-up was 24 months. One multiple-wire and 2 single-wire patients developed in-breast recurrences ( P = .84). No distant metastases developed among the multiple-wire patients. Additional follow-up imaging was obtained in 29% of multiple-wire and 22% of single-wire cases ( P = .1). Seven (6%) of the multiple-wire and 11 (6%) of the single-wire cases underwent biopsy ( P = .94). Conclusions We found no increased risk of early local recurrence, metastasis, or additional imaging or biopsies in patients requiring multiple-wire localization for lumpectomy. Breast conservation should be considered a safe option even for patients with mammographically extensive lesions.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2009.01.021