Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions

Hydrophilic ionic liquids dissociate into individual ions in water. The effect of individual ions on the enzyme activity follows the Hofmeister series: kosmotropic anions and chaotropic cations stabilize the enzyme. This paper examined the effect of several pyridinium and imidazolium-based ionic liq...

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Bibliographic Details
Published in:Bioorganic chemistry 2006-02, Vol.34 (1), p.15-25
Main Authors: Zhao, Hua, Olubajo, Olarongbe, Song, Zhiyan, Sims, Artez L., Person, Terra E., Lawal, Rasheed A., Holley, LaDena A.
Format: Article
Language:English
Subjects:
Acetic Acid - chemistry
Activity
Aspergillus - enzymology
Chaotrope
Enzyme
Enzyme Stability
Imidazoles - chemistry
Ionic liquid
Ions
Kosmotrope
Kosmotropicity
Peptide Hydrolases - chemistry
Peptide Hydrolases - metabolism
Pyridines - chemistry
Solutions - chemistry
Stability
Time Factors
Trifluoroacetic Acid - chemistry
Water - chemistry
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Summary:Hydrophilic ionic liquids dissociate into individual ions in water. The effect of individual ions on the enzyme activity follows the Hofmeister series: kosmotropic anions and chaotropic cations stabilize the enzyme. This paper examined the effect of several pyridinium and imidazolium-based ionic liquids (ILs) on the protease stability in aqueous solutions. In general, the enzyme was found quite active at low concentrations of hydrophilic ILs. In aqueous environment, the enzyme was stabilized by the kosmotropic anions (such as CF 3COO − and CH 3COO −) and chaotropic cations (such as [BuPy] + and [EMIM] +), but was destabilized by chaotropic anions (such as tosylate and BF 4 −) and kosmotropic cations (such as [BMIM] +).
ISSN:0045-2068
1090-2120
DOI:10.1016/j.bioorg.2005.10.004