Differential effects of distraction during working memory on delay-period activity in the prefrontal cortex and the visual association cortex

Maintaining relevant information for later use is a critical aspect of working memory (WM). The lateral prefrontal cortex (PFC) and posterior sensory cortical areas appear to be important in supporting maintenance. However, the relative and unique contributions of these areas remain unclear. We have...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006-02, Vol.29 (4), p.1117-1126
Main Authors: Yoon, Jong H., Curtis, Clayton E., D'Esposito, Mark
Format: Article
Language:English
Subjects:
Adult
Association Learning - physiology
Attention - physiology
Behavior
Brain Mapping
Cognition
Event-related fMRI
Face
Female
Functional connectivity
Humans
Magnetic Resonance Imaging
Male
Memory
Memory, Short-Term - physiology
Nerve Net - physiology
Prefrontal cortex
Prefrontal Cortex - physiology
Psychophysics
Reaction Time - physiology
Retention (Psychology) - physiology
Studies
Visual association cortex
Visual Cortex - physiology
Visual Pathways - physiology
Working memory
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Summary:Maintaining relevant information for later use is a critical aspect of working memory (WM). The lateral prefrontal cortex (PFC) and posterior sensory cortical areas appear to be important in supporting maintenance. However, the relative and unique contributions of these areas remain unclear. We have designed a WM paradigm with distraction to probe the contents of maintenance representations in these regions. During delayed recognition trials of faces, selective interference was evident behaviorally with face distraction leading to significantly worse performance than with scene distraction. Event-related fMRI of the human brain showed that maintenance activity in the lateral PFC, but not in visual association cortex (VAC), was selectively disrupted by face distraction. Additionally, the functional connectivity between the lateral PFC and the VAC was perturbed during these trials. We propose a hierarchical and distributed model of active maintenance in which the lateral PFC codes for abstracted mnemonic information, while sensory areas represent specific features of the memoranda. Furthermore, persistent coactivation between the PFC and sensory areas may be a mechanism by which information is actively maintained.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2005.08.024