Total Synthesis, Structural Revision, and Absolute Configuration of (+)-Clavosolide A

Enantioselective synthesis of 3, a revised structure for clavosolide A, was completed. Both 1H and 13C NMR spectra of the natural and synthetic compounds were identical, and optical rotation measurements identified the absolute configuration of the natural clavosolide A as the enantiomer of 3.

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Bibliographic Details
Published in:Organic letters 2006-02, Vol.8 (4), p.661-664
Main Authors: Son, Jung Beom, Kim, Si Nae, Kim, Na Yeong, Lee, Duck Hyung
Format: Article
Language:English
Subjects:
Animals
Macrolides - chemical synthesis
Macrolides - chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera - chemistry
Stereoisomerism
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Summary:Enantioselective synthesis of 3, a revised structure for clavosolide A, was completed. Both 1H and 13C NMR spectra of the natural and synthetic compounds were identical, and optical rotation measurements identified the absolute configuration of the natural clavosolide A as the enantiomer of 3.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052851n