Turmeric reduces inflammatory cells in hamster opisthorchiasis

The curcumin compound from turmeric is effective in the treatment of many inflammatory diseases. The aim of our present study was to evaluate the efficacy of turmeric on reducing the histopathological changes of hamster opisthorchiasis. Hamsters were infected with Opisthorchis viverrini and then adm...

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Published in:Parasitology research (1987) 2009-10, Vol.105 (5), p.1459-1463
Main Authors: Boonjaraspinyo, Sirintip, Boonmars, Thidarut, Aromdee, Chantana, Srisawangwong, Tuanchai, Kaewsamut, Butsara, Pinlaor, Somchai, Yongvanit, Puangrat, Puapairoj, Anucha
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cricetinae
Curcuma - chemistry
Curcuma longa
Curcumin - isolation & purification
Curcumin - therapeutic use
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Immunology
Invertebrates
Liver - parasitology
Liver - pathology
Liver Function Tests
Medical Microbiology
Mesocricetus
Microbiology
Opisthorchiasis - drug therapy
Opisthorchiasis - pathology
Opisthorchis - growth & development
Opisthorchis - pathogenicity
Opisthorchis viverrini
Short Communication
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Summary:The curcumin compound from turmeric is effective in the treatment of many inflammatory diseases. The aim of our present study was to evaluate the efficacy of turmeric on reducing the histopathological changes of hamster opisthorchiasis. Hamsters were infected with Opisthorchis viverrini and then administered turmeric. Using light microscopic observation, liver function tests for alanine transaminase (ALT), alkaline phosphatase, and direct bilirubin were investigated. The resulting histopathological changes show that turmeric has anti-inflammatory properties--during both N-nitrosodimethylamine administration and O. viverrini infection--by reducing the aggregation of inflammatory cells surrounding the hepatic bile ducts, which correlates with a decreased serum ALT level. The decrease in direct bilirubin levels in the hamsters treated with turmeric suggests that turmeric may enhance biliary contraction. The present study found that turmeric clearly reduces the inflammatory cells in hamster opisthorchiasis at an early stage. This finding may be connected with a reduction in the risk factors of cholangiocarcinoma development.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-009-1553-3