Angiogenesis and p53 at the Invading Tumor Edge: Prognostic Markers for Colorectal Cancer Beyond Stage

Angiogenesis has emerged as a major prognostic factor in many human malignancies and it is a prospective target for cancer therapy. In this study, we investigated immunohistochemically the angiogenic activity and the expression of p53 and bcl-2 proteins in a series of 170 operable colorectal carcino...

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Published in:The Journal of surgical research 2006-03, Vol.131 (1), p.118-123
Main Authors: Georgiou, Loucas, Minopoulos, George, Lirantzopoulos, Nikos, Fiska-Demetriou, Aliki, Maltezos, Efstratios, Sivridis, Efthimios
Format: Article
Language:English
Subjects:
angiogenesis
bcl-2
Biological and medical sciences
Biomarkers, Tumor - analysis
colorectal cancer
Colorectal Neoplasms - pathology
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Immunohistochemistry
Lymphatic Metastasis
Medical sciences
Neoplasm Invasiveness
Neoplasm Staging
Neovascularization, Pathologic
p53
Prognosis
Proto-Oncogene Proteins c-bcl-2 - analysis
Proto-Oncogene Proteins c-bcl-2 - biosynthesis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tumor Suppressor Protein p53 - analysis
Tumor Suppressor Protein p53 - biosynthesis
Tumors
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Summary:Angiogenesis has emerged as a major prognostic factor in many human malignancies and it is a prospective target for cancer therapy. In this study, we investigated immunohistochemically the angiogenic activity and the expression of p53 and bcl-2 proteins in a series of 170 operable colorectal carcinomas, stage B and C. A high vascular density at the invading tumor front was directly related to nuclear p53 accumulation, and inversely to cytoplasmic expression of bcl-2. Furthermore, high angiogenic activity was significantly associated with lymph node metastasis. Survival analysis showed that Dukes stage and vascular density were the most important and independent prognostic factors in colorectal cancer. It is believed that angiogenesis at the invading tumor edge can be used as an independent prognostic marker to identify subgroups of colorectal cancer patients with an unfavorable post-operative outcome.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2005.10.002