Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis

We investigated an effect of extremely low frequency magnetic field (ELF-MF, 60 Hz) on hyperalgesia using hot plate test. The level of nitric oxide (NO) and the expression of nitric oxide synthase (NOS) were measured to determine if ELF-MF is engaged in NO mediated pain mechanism. Additionally, the...

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Bibliographic Details
Published in:Life sciences (1973) 2006-02, Vol.78 (13), p.1407-1412
Main Authors: Jeong, Ji Hoon, Kum, Chan, Choi, Hee Jung, Park, Eon Sub, Sohn, Uy Dong
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - physiology
Calcium Channel Blockers - pharmacology
Disease Models, Animal
Dizocilpine Maleate - pharmacology
Electromagnetic Fields - adverse effects
Extremely low frequency magnetic field
Hot Temperature
Hyperalgesia
Hyperalgesia - etiology
Male
Mice
Mice, Inbred ICR
Nitric oxide
Nitric Oxide - biosynthesis
Nitric Oxide Synthase - metabolism
Spinal Cord - drug effects
Spinal Cord - physiology
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Summary:We investigated an effect of extremely low frequency magnetic field (ELF-MF, 60 Hz) on hyperalgesia using hot plate test. The level of nitric oxide (NO) and the expression of nitric oxide synthase (NOS) were measured to determine if ELF-MF is engaged in NO mediated pain mechanism. Additionally, the involvement of Ca 2+-dependent NO pathway in ELF-MF induced hyperalgesia was evaluated by blocking Ca 2+ sources with NMDA receptor antagonist and Ca 2+ channel blocker. The exposure of mice to ELF-MF lowered pain threshold and elevated NO synthesis in brain and spinal cord. An NOS inhibitor blocked these effects of ELF-MF with attenuating the reduction of pain threshold and the rise of NO level in brain and spine by the exposure of ELF-MF. The hyperalgesic effects of ELF-MF were also blocked by a Ca 2+ channel blocker, nimodipine, but not by a NMDA receptor antagonist, MK-801. The expression of Ca 2+-dependent nNOS and eNOS and Ca 2+-independent iNOS were not changed by ELF-MF. These results indicated that the exposure of ELF-MF might cause Ca 2+-dependent NOS activation, which then induces hyperalgesia with the increase in NO synthesis. In conclusion, ELF-MF may produce hyperalgesia by modulating NO synthesis via Ca 2+-dependent NOS.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2005.07.006