Cutaneous hypersensitivity to Malassezia sympodialis and dust mite in adult atopic dermatitis with a textile pattern

Atopic dermatitis (AD) patients with predominantly head and neck involvement react to patch tests of the yeast Malassezia sympodialis (Ms). Protein patch testing methods and interpretation are controversial, but subgroups of AD patients may have unique triggers for disease activity. The aim of the s...

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Bibliographic Details
Published in:Contact dermatitis 2006-02, Vol.54 (2), p.92-99
Main Authors: Ramirez De Knott, Haydee M., Mccormick, Thomas S., Kalka, Katrin, Skandamis, George, Ghannoum, Mahmoud A., Schluchter, Mark, Cooper, Kevin D., Nedorost, Susan T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Allergens - immunology
Allergic diseases
Animals
Antigens, Dermatophagoides - immunology
atopic dermatitis
atopy patch test
Biological and medical sciences
Case-Control Studies
Dermatitis, Allergic Contact - diagnosis
Dermatitis, Allergic Contact - etiology
Dermatitis, Allergic Contact - immunology
Dermatitis, Allergic Contact - pathology
Dermatitis, Atopic - diagnosis
Dermatitis, Atopic - etiology
Dermatitis, Atopic - immunology
Dermatitis, Atopic - pathology
Dermatophagoides
dust mite
Female
Head
Humans
Immunopathology
Malassezia - immunology
Malassezia sympodialis
Male
Medical sciences
Middle Aged
Neck
Patch Tests
protein contact dermatitis
Pyroglyphidae - immunology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Skin allergic diseases. Stinging insect allergies
textile-pattern dermatitis
Th1 Cells - immunology
Th2 Cells - immunology
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Summary:Atopic dermatitis (AD) patients with predominantly head and neck involvement react to patch tests of the yeast Malassezia sympodialis (Ms). Protein patch testing methods and interpretation are controversial, but subgroups of AD patients may have unique triggers for disease activity. The aim of the study was to identify clinical characteristics of patients who are patch test‐positive to Dermatophagoides farinae/pteronyssinus (Df) and Ms and characterize cutaneous cytokine profiles of the atopy patch tests (APTs). 25 AD patients and 27 control dermatitis patients were patch tested with Ms and Df. Qualitative analysis of Th‐1 and Th‐2 cytokines by RT‐PCR mRNA was obtained from positive APTs. Atopic dermatitis patients with a textile pattern or head and neck involvement demonstrated more positive APTs to Ms than control patients. Early positive APTs (
ISSN:0105-1873
1600-0536
DOI:10.1111/j.0105-1873.2006.00774.x