Pregnancy Prevents Hypertensive Remodeling of Cerebral Arteries: A Potential Role in the Development of Eclampsia

We investigated how hypertension during pregnancy affected passive structural (wall:lumen, wall stress) and active (myogenic activity) responses of the cerebral circulation. Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals w...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2006-03, Vol.47 (3, Part 2 Suppl), p.619-626
Main Authors: Cipolla, Marilyn J, DeLance, Nicole, Vitullo, Lisa
Format: Article
Language:English
Subjects:
Animals
Antihypertensive agents
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Blood-Brain Barrier
Cardiology. Vascular system
Cardiovascular system
Cerebral Arteries - pathology
Cerebral Arteries - physiopathology
Eclampsia - etiology
Enzyme Inhibitors - pharmacology
Experimental diseases
Female
Gestational Age
Homeostasis
Hypertension - complications
Hypertension - pathology
Hypertension - physiopathology
Medical sciences
Microscopy, Video
Nitric Oxide Synthase - antagonists & inhibitors
Nitroarginine - pharmacology
Pharmacology. Drug treatments
Pre-Eclampsia - chemically induced
Pre-Eclampsia - physiopathology
Pregnancy
Pregnancy Complications, Cardiovascular - physiopathology
Rats
Rats, Sprague-Dawley
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Summary:We investigated how hypertension during pregnancy affected passive structural (wall:lumen, wall stress) and active (myogenic activity) responses of the cerebral circulation. Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals were treated with the NO synthase inhibitor nitro-l-arginine in their drinking water to raise blood pressure. LP rats (n=6) were treated for the last 7 days of pregnancy (last trimester) to mimic preeclampsia and compared with NP rats treated for the same duration (n=8). Active and passive responses were determined on isolated and pressurized third-order posterior cerebral arteries. Nitro-l-arginine treatment significantly raised blood pressure in both groups of animals that was associated with increased wall thickness and wall:lumen ratio in the NP hypertensive animals versus controls (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000196948.15019.28