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Pregnancy Prevents Hypertensive Remodeling of Cerebral Arteries: A Potential Role in the Development of Eclampsia
We investigated how hypertension during pregnancy affected passive structural (wall:lumen, wall stress) and active (myogenic activity) responses of the cerebral circulation. Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals w...
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| Published in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2006-03, Vol.47 (3, Part 2 Suppl), p.619-626 |
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| container_end_page | 626 |
| container_issue | 3, Part 2 Suppl |
| container_start_page | 619 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 47 |
| creator | Cipolla, Marilyn J DeLance, Nicole Vitullo, Lisa |
| description | We investigated how hypertension during pregnancy affected passive structural (wall:lumen, wall stress) and active (myogenic activity) responses of the cerebral circulation. Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals were treated with the NO synthase inhibitor nitro-l-arginine in their drinking water to raise blood pressure. LP rats (n=6) were treated for the last 7 days of pregnancy (last trimester) to mimic preeclampsia and compared with NP rats treated for the same duration (n=8). Active and passive responses were determined on isolated and pressurized third-order posterior cerebral arteries. Nitro-l-arginine treatment significantly raised blood pressure in both groups of animals that was associated with increased wall thickness and wall:lumen ratio in the NP hypertensive animals versus controls (P |
| doi_str_mv | 10.1161/01.HYP.0000196948.15019.28 |
| format | article |
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Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals were treated with the NO synthase inhibitor nitro-l-arginine in their drinking water to raise blood pressure. LP rats (n=6) were treated for the last 7 days of pregnancy (last trimester) to mimic preeclampsia and compared with NP rats treated for the same duration (n=8). Active and passive responses were determined on isolated and pressurized third-order posterior cerebral arteries. Nitro-l-arginine treatment significantly raised blood pressure in both groups of animals that was associated with increased wall thickness and wall:lumen ratio in the NP hypertensive animals versus controls (P<0.05). In contrast, this response to pressure was absent in LP animals, which had similar wall measurements. In addition, arteries from NP hypertensive animals had increased myogenic tone and pressure of forced dilatation compared with NP control animals (P<0.01). Again, this response was lacking in the LP hypertensive animals that had similar tone and pressure of forced dilatation as normotensive controls. The increased tone and wall thickness decreased wall stress in the NP hypertensive animals, a response that did not occur in LP hypertensive animals. Because medial hypertrophy is considered a protective response to elevated blood pressure, these results suggest that hypertension in pregnancy may predispose the cerebral circulation to autoregulatory breakthrough and blood–brain–barrier disruption when blood pressure is elevated, as during eclampsia.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.0000196948.15019.28</identifier><identifier>PMID: 16380541</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Antihypertensive agents ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood-Brain Barrier ; Cardiology. Vascular system ; Cardiovascular system ; Cerebral Arteries - pathology ; Cerebral Arteries - physiopathology ; Eclampsia - etiology ; Enzyme Inhibitors - pharmacology ; Experimental diseases ; Female ; Gestational Age ; Homeostasis ; Hypertension - complications ; Hypertension - pathology ; Hypertension - physiopathology ; Medical sciences ; Microscopy, Video ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitroarginine - pharmacology ; Pharmacology. Drug treatments ; Pre-Eclampsia - chemically induced ; Pre-Eclampsia - physiopathology ; Pregnancy ; Pregnancy Complications, Cardiovascular - physiopathology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2006-03, Vol.47 (3, Part 2 Suppl), p.619-626</ispartof><rights>2006 American Heart Association, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3764-8bf2cff5b4f3f47a660a4057a25602225f350163a938cab4d8460401da2a7fd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,777,781,786,787,23912,23913,25122,27906,27907</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17592289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16380541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cipolla, Marilyn J</creatorcontrib><creatorcontrib>DeLance, Nicole</creatorcontrib><creatorcontrib>Vitullo, Lisa</creatorcontrib><title>Pregnancy Prevents Hypertensive Remodeling of Cerebral Arteries: A Potential Role in the Development of Eclampsia</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We investigated how hypertension during pregnancy affected passive structural (wall:lumen, wall stress) and active (myogenic activity) responses of the cerebral circulation. Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals were treated with the NO synthase inhibitor nitro-l-arginine in their drinking water to raise blood pressure. LP rats (n=6) were treated for the last 7 days of pregnancy (last trimester) to mimic preeclampsia and compared with NP rats treated for the same duration (n=8). Active and passive responses were determined on isolated and pressurized third-order posterior cerebral arteries. Nitro-l-arginine treatment significantly raised blood pressure in both groups of animals that was associated with increased wall thickness and wall:lumen ratio in the NP hypertensive animals versus controls (P<0.05). In contrast, this response to pressure was absent in LP animals, which had similar wall measurements. In addition, arteries from NP hypertensive animals had increased myogenic tone and pressure of forced dilatation compared with NP control animals (P<0.01). Again, this response was lacking in the LP hypertensive animals that had similar tone and pressure of forced dilatation as normotensive controls. The increased tone and wall thickness decreased wall stress in the NP hypertensive animals, a response that did not occur in LP hypertensive animals. Because medial hypertrophy is considered a protective response to elevated blood pressure, these results suggest that hypertension in pregnancy may predispose the cerebral circulation to autoregulatory breakthrough and blood–brain–barrier disruption when blood pressure is elevated, as during eclampsia.</description><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood-Brain Barrier</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Cerebral Arteries - pathology</subject><subject>Cerebral Arteries - physiopathology</subject><subject>Eclampsia - etiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Experimental diseases</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Homeostasis</subject><subject>Hypertension - complications</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Medical sciences</subject><subject>Microscopy, Video</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitroarginine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pre-Eclampsia - chemically induced</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpFkFtv0zAUgC0EYqXwF5CFBG8JvsVx9laVsSJNoppAgifLSY7XgHOZnW7qv9_ZWql-8dHxdy7-CPnEWc655l8Zzzd_tznDwytdKZPzAqNcmFdkwQuhMlVo-ZosMKmyivM_F-RdSv8QV0qVb8kF19KwQvEFud9GuBvc0BwoRg8wzIluDhPEGYbUPQC9hX5sIXTDHR09XUOEOrpAVwjEDtIlXdHtiPDcYfZ2DEC7gc47oN-wWxinHp-eK6-a4Popde49eeNdSPDhdC_J7-9Xv9ab7Obn9Y_16iZrZKlVZmovGu-LWnnpVem0Zk6xonSi0EwIUXiJn9bSVdI0rlatUZopxlsnXOlbJZfky7HvFMf7PaTZ9l1qIAQ3wLhPVpdaVxpFLcnlEWzimFIEb6fY9S4eLGf2Wbhl3KJwexZuX4RbYbD442nKvu6hPZeeDCPw-QS41LjgI7ru0pkri0oIUyGnjtzjGFBt-h_2jxDtDlyYdy-jldAmE4xpJnGPDDNCySfYVJlq</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Cipolla, Marilyn J</creator><creator>DeLance, Nicole</creator><creator>Vitullo, Lisa</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Pregnancy Prevents Hypertensive Remodeling of Cerebral Arteries: A Potential Role in the Development of Eclampsia</title><author>Cipolla, Marilyn J ; DeLance, Nicole ; Vitullo, Lisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3764-8bf2cff5b4f3f47a660a4057a25602225f350163a938cab4d8460401da2a7fd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood-Brain Barrier</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Cerebral Arteries - pathology</topic><topic>Cerebral Arteries - physiopathology</topic><topic>Eclampsia - etiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Experimental diseases</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Homeostasis</topic><topic>Hypertension - complications</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Medical sciences</topic><topic>Microscopy, Video</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitroarginine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pre-Eclampsia - chemically induced</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cipolla, Marilyn J</creatorcontrib><creatorcontrib>DeLance, Nicole</creatorcontrib><creatorcontrib>Vitullo, Lisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cipolla, Marilyn J</au><au>DeLance, Nicole</au><au>Vitullo, Lisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy Prevents Hypertensive Remodeling of Cerebral Arteries: A Potential Role in the Development of Eclampsia</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2006-03</date><risdate>2006</risdate><volume>47</volume><issue>3, Part 2 Suppl</issue><spage>619</spage><epage>626</epage><pages>619-626</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We investigated how hypertension during pregnancy affected passive structural (wall:lumen, wall stress) and active (myogenic activity) responses of the cerebral circulation. Female nonpregnant (NP; n=8) Sprague Dawley rats were compared with late-pregnant (LP; day 19 to 20, n=6) rats. Some animals were treated with the NO synthase inhibitor nitro-l-arginine in their drinking water to raise blood pressure. LP rats (n=6) were treated for the last 7 days of pregnancy (last trimester) to mimic preeclampsia and compared with NP rats treated for the same duration (n=8). Active and passive responses were determined on isolated and pressurized third-order posterior cerebral arteries. Nitro-l-arginine treatment significantly raised blood pressure in both groups of animals that was associated with increased wall thickness and wall:lumen ratio in the NP hypertensive animals versus controls (P<0.05). In contrast, this response to pressure was absent in LP animals, which had similar wall measurements. In addition, arteries from NP hypertensive animals had increased myogenic tone and pressure of forced dilatation compared with NP control animals (P<0.01). Again, this response was lacking in the LP hypertensive animals that had similar tone and pressure of forced dilatation as normotensive controls. The increased tone and wall thickness decreased wall stress in the NP hypertensive animals, a response that did not occur in LP hypertensive animals. Because medial hypertrophy is considered a protective response to elevated blood pressure, these results suggest that hypertension in pregnancy may predispose the cerebral circulation to autoregulatory breakthrough and blood–brain–barrier disruption when blood pressure is elevated, as during eclampsia.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>16380541</pmid><doi>10.1161/01.HYP.0000196948.15019.28</doi><tpages>8</tpages></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 2006-03, Vol.47 (3, Part 2 Suppl), p.619-626 |
| issn | 0194-911X 1524-4563 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antihypertensive agents Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood-Brain Barrier Cardiology. Vascular system Cardiovascular system Cerebral Arteries - pathology Cerebral Arteries - physiopathology Eclampsia - etiology Enzyme Inhibitors - pharmacology Experimental diseases Female Gestational Age Homeostasis Hypertension - complications Hypertension - pathology Hypertension - physiopathology Medical sciences Microscopy, Video Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Pharmacology. Drug treatments Pre-Eclampsia - chemically induced Pre-Eclampsia - physiopathology Pregnancy Pregnancy Complications, Cardiovascular - physiopathology Rats Rats, Sprague-Dawley |
| title | Pregnancy Prevents Hypertensive Remodeling of Cerebral Arteries: A Potential Role in the Development of Eclampsia |
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