Serum immunoglobulin levels do not affect antibody responses to influenza HA vaccine in preterm infants

Antibody responses to two doses of influenza hemagglutinin (HA) vaccine were evaluated in 45 previously unimmunized preterm infants aged 6–11 months before the 2003/2004 influenza season. Twenty-three (51.1%), 21 (46.6%) and 2 (4.4%) of the subjects acquired protective (≥1:40) hemagglutination inhib...

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Bibliographic Details
Published in:Vaccine 2006-03, Vol.24 (12), p.2208-2212
Main Authors: Sasaki, Yuka, Kusuhara, Koichi, Saito, Mitsumasa, Hikino, Shunji, Murayama, Yasuo, Yamashita, Hironori, Matsumoto, Naoko, Kukita, Johji, Kinukawa, Naoko, Hara, Toshiro
Format: Article
Language:English
Subjects:
Antibodies, Viral - biosynthesis
Antibody Formation
Applied microbiology
Babies
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Humans
Hypogammaglobulinemia
Immune system
Infant, Newborn
Infant, Premature
Infants
Influenza A virus
Influenza vaccination to preterm infants
Influenza vaccine
Influenza Vaccines - immunology
Male
Microbiology
Mortality
Multivariate analysis
Premature birth
Preterm infants
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Antibody responses to two doses of influenza hemagglutinin (HA) vaccine were evaluated in 45 previously unimmunized preterm infants aged 6–11 months before the 2003/2004 influenza season. Twenty-three (51.1%), 21 (46.6%) and 2 (4.4%) of the subjects acquired protective (≥1:40) hemagglutination inhibition (HI) antibody titers after vaccination for A/New Caledonia (H1N1), A/Panama (H3N2) and B/Shandong, respectively. Antibody responses to A (H1N1), A (H3N2) appeared to be comparable to those reported on full-term infants of similar ages vaccinated with the identical vaccine. Serum IgG levels at vaccination had no positive association with antibody responses on univariate or multivariate analysis, indicating that prolonged hypogammaglobulinemia after 6 months of age in preterm infants was not a factor to affect antibody responses to influenza HA vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.11.001