A Novel Route to Dipeptides via Noncondensation of Amino Acids:  2-Aminoperfluoropropene as a Synthon for Trifluoroalanine Dipeptides

2-Aminoperfluoropropene has been prepared by the Mg-promoted defluorinative N-silylation of N - p-methoxyphenyl hexafluoroacetone imine and has been employed as a synthon of trifluoroalanine for the preparation of trifluoroalanine dipeptides.

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Bibliographic Details
Published in:Organic letters 2006-03, Vol.8 (5), p.827-829
Main Authors: Guo, Yong, Fujiwara, Kana, Uneyama, Kenji
Format: Article
Language:English
Subjects:
Alanine - analogs & derivatives
Alanine - chemistry
Amino Acids - chemistry
Combinatorial Chemistry Techniques
Dipeptides - chemical synthesis
Dipeptides - chemistry
Fluorocarbons - chemistry
Magnesium - chemistry
Molecular Structure
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Summary:2-Aminoperfluoropropene has been prepared by the Mg-promoted defluorinative N-silylation of N - p-methoxyphenyl hexafluoroacetone imine and has been employed as a synthon of trifluoroalanine for the preparation of trifluoroalanine dipeptides.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0526726