Interleukin-10 −1082 G/A polymorphism and risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants

• Published in: Pediatric pulmonology 2005-05, Vol.39 (5), p.426-432
• Main Authors: Yanamandra, Krishna, Boggs, Peter, Loggins, John, Baier, R. John
• Format: Article
• Language: English
• Subjects: Adenine; Alleles; Biological and medical sciences; bronchopulmonary dysplasia; Bronchopulmonary Dysplasia - genetics; Case-Control Studies; Cause of Death; Diseases of mother, fetus and pregnancy; Ethnic Groups - genetics; Female; Gene Frequency; gene polymorphism; Genotype; Guanine; Gynecology. Andrology. Obstetrics; Heterozygote; Homozygote; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; interleukin-10; Interleukin-10 - genetics; Male; Medical sciences; Pneumology; Polymorphism, Single Nucleotide - genetics; Pregnancy. Fetus. Placenta; prematurity; Prospective Studies; Respiration, Artificial; Respiratory system : syndromes and miscellaneous diseases; Risk Factors; Sex Factors; Trachea - microbiology
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.20182

IL‐10 is an anti‐inflammatory cytokine that may have a protective role in acute lung injury. IL‐10 expression is affected by a single‐nucleotide polymorphism (SNP) located at position −1082 (G to A). The A allele is associated with lower IL‐10 production. Low IL‐10 production has been linked to the development of BPD. Thus, the IL‐10 −1082 SNP may be a genetic risk factor for the development of BPD in the premature newborn. The IL‐10 −1082 SNP was determined in 294 (235 African American, 56 Caucasian, and 3 Hispanic) mechanically ventilated very low birth weight (VLBW) infants and compared to outcome (death and/or development of BPD). Differences in groups were analyzed using ANOVA (continuous variables) or chi square (proportions). The frequency of the A allele in our population was 0.62. Thirty‐nine (13.3%) infants were homozygous GG, 146 (49.7%) were heterozygous GA, and 109 (37.0%) were homozygous AA. There were no significant differences between genotype groups with respect to ethnic origin, gender, need for surfactant replacement therapy, and isolation of Ureaplasma urealyticum or Mycoplasma hominis from tracheal aspirates at birth. However, AA infants were slightly more mature and of greater birth weight than GA infants (26.9 ± 0.2 weeks vs. 26.3 ± 0.2 weeks, P