Long‐lived yeast as a model for ageing research

Yeast has essentially two lifespans: a replicative lifespan (the number of daughters produced by each dividing mother cell) and a chronological lifespan (the capacity of stationary (G0) cultures to maintain viability over time). There is a tendency now to label every investigation that addresses the...

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Bibliographic Details
Published in:Yeast (Chichester, England) England), 2006-02, Vol.23 (3), p.215-226
Main Author: Piper, Peter W.
Format: Article
Language:English
Subjects:
ageing
Aging - physiology
chronological lifespan
Humans
longevity
Models, Biological
oxidative stress
replicative lifespan
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae - metabolism
Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
stationary survival
Time Factors
yeast
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Summary:Yeast has essentially two lifespans: a replicative lifespan (the number of daughters produced by each dividing mother cell) and a chronological lifespan (the capacity of stationary (G0) cultures to maintain viability over time). There is a tendency now to label every investigation that addresses these lifespans as ageing research. It is, though, analyses of the longest lifespans that will be most informative about the determinants of longevity and yield results most relevant to ageing in more complex systems. This review addresses these issues and describes the ongoing studies that are now attempting to address ageing in yeast cells of maximal replicative or chronological longevity. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0749-503X
1097-0061
DOI:10.1002/yea.1354