Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement

Systemic sclerosis (SSc) is a chronic, multisystemic, autoimmune disease characterised by vascular changes and varying degrees of fibrosis of the skin and visceral organs. Organ systemic involvement in SSc is associated with an altered function of endothelial cells, perivascular infiltrating mononuc...

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Bibliographic Details
Published in:Clinical rheumatology 2005-04, Vol.24 (2), p.111-116
Main Authors: Kuryliszyn-Moskal, Anna, Klimiuk, Piotr Adrian, Sierakowski, Stanislaw
Format: Article
Language:English
Subjects:
Biomarkers
Cell adhesion & migration
E-Selectin - blood
Endothelin-1 - blood
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Proteins
Scleroderma, Systemic - blood
Scleroderma, Systemic - physiopathology
Severity of Illness Index
Solubility
Vascular Cell Adhesion Molecule-1 - blood
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
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Summary:Systemic sclerosis (SSc) is a chronic, multisystemic, autoimmune disease characterised by vascular changes and varying degrees of fibrosis of the skin and visceral organs. Organ systemic involvement in SSc is associated with an altered function of endothelial cells, perivascular infiltrating mononuclear cells and interstitial fibrosis. To evaluate the relationship between systemic manifestations and immunological markers of endothelial cell activation, serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) were determined by an enzyme-linked immunosorbent assay in 31 SSc patients and in 30 healthy controls. In comparison with the control group, higher serum concentrations of sVCAM-1, sE-selectin, VEGF and ET-1 were detected in SSc patients (in all cases p
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-004-0987-3