Maternal 25-Hydroxyvitamin D and Parathyroid Hormone Concentrations and Offspring Birth Size

Context: There is inconsistent evidence that maternal 25-hydroxyvitamin D [25-(OH)D] deficiency may impair fetal growth. Objective: The objective of the study was to examine the relationship between maternal 25-(OH)D and PTH concentrations at less than 16 and 28 wk gestation and offspring birth size...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2006-03, Vol.91 (3), p.906-912
Main Authors: Morley, Ruth, Carlin, John B., Pasco, Julie A., Wark, John D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth Weight
Body Size
Calcifediol - blood
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Infant, Newborn
Medical sciences
Parathyroid Hormone - blood
Pregnancy
Prenatal Care
Regression Analysis
Seasons
Skinfold Thickness
Vertebrates: endocrinology
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Summary:Context: There is inconsistent evidence that maternal 25-hydroxyvitamin D [25-(OH)D] deficiency may impair fetal growth. Objective: The objective of the study was to examine the relationship between maternal 25-(OH)D and PTH concentrations at less than 16 and 28 wk gestation and offspring birth size. Design: This was an observational study. Setting: The study was set at a hospital antenatal clinic. Participants: Women with singleton pregnancies, before 16 wk gestation, participated. Interventions: No interventions were used. Main Outcome Measure: Knee-heel length at birth was the main outcome measure. Results: Altogether 374 of 475 (79%) women completed this study. We found no evident relationship between birth size measures and maternal 25-(OH)D or PTH at recruitment (∼11 wk). Gestation length was 0.7 wk (95% confidence interval −1.3, −0.1) shorter and knee-heel length was 4.3 mm smaller (−7.3, −1.3) in infants of 27 mothers with low 25-(OH)D (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2005-1479