The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells

Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell...

Full description

Saved in:
Bibliographic Details
Published in:Cancer cell 2006-03, Vol.9 (3), p.209-223
Main Authors: Su, Jen-Liang, Yang, Pan-Chyr, Shih, Jin-Yuan, Yang, Ching-Yao, Wei, Lin-Hung, Hsieh, Chang-Yao, Chou, Chia-Hung, Jeng, Yung-Ming, Wang, Ming-Yang, Chang, King-Jen, Hung, Mien-Chie, Kuo, Min-Liang
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Animals
Cell Adhesion Molecules, Neuronal - metabolism
Cell Movement
Contactin 1
Contactins
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lymphatic Metastasis - pathology
Male
Mice
Middle Aged
Mitogen-Activated Protein Kinases - metabolism
Neoplasm Invasiveness - pathology
Reverse Transcriptase Polymerase Chain Reaction
SIGNALING
Vascular Endothelial Growth Factor C - metabolism
Vascular Endothelial Growth Factor Receptor-3 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2006.02.018