Fangchinoline inhibited the antinociceptive effect of morphine in mice

Fangchinoline (FAN), a non-specific calcium antagonist, is a major alkaloidal component of the creeper Stephania tetrandra S. Moore (or fenfangji). It has been shown to possess antagonistic activity on morphine-induced antinociception in mice. This study was undertaken to assess the antagonistic mec...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2005-03, Vol.12 (3), p.183-188
Main Authors: Fang, L.-H., Zhang, Y.-H., Ku, B.-S.
Format: Article
Language:English
Subjects:
alkaloids
Alkaloids - administration & dosage
Alkaloids - pharmacology
Alkaloids - therapeutic use
analgesia
analgesic effect
Animals
antagonists
Antibiosis
Antinociception
Benzylisoquinolines - administration & dosage
Benzylisoquinolines - pharmacology
Benzylisoquinolines - therapeutic use
Dose-Response Relationship, Drug
Fangchinoline
herbal medicines
Injections, Intraperitoneal
Male
medicinal plants
medicinal properties
Medicine, Botanic
Medicine, Herbal
Mice
Mice, Inbred ICR
Morphine
Narcotic Antagonists - administration & dosage
Narcotic Antagonists - pharmacology
Narcotic Antagonists - therapeutic use
pain
Pain Measurement - drug effects
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Serotonin
Stephania
Stephania tetrandra
Tolerance
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Summary:Fangchinoline (FAN), a non-specific calcium antagonist, is a major alkaloidal component of the creeper Stephania tetrandra S. Moore (or fenfangji). It has been shown to possess antagonistic activity on morphine-induced antinociception in mice. This study was undertaken to assess the antagonistic mechanism. The results demonstrated that FAN (IP) attenuated morphine (SC)-induced antinociception in a dose-dependent manner with significant effect at doses of 30 and 60 mg/kg body wt. (IP) in the tail-flick test but not the tail-pinch tests, carried out in mice. This antagonism was abolished by pretreatment with a serotonin precursor, 5-hydroxytryptophan (5-HTP, IP), but not by pretreatment with a noradrenaline precursor, l-dihydroxyphenylalanine ( l-DOPA, IP) in the tail-flick test. On the other hand, the development of morphine-induced analgesic tolerance was not prevented by FAN. These results suggest that the serotonergic pathway may be involved in the antagonism of morphine-induced antinociception by FAN and, in agreement with other reports, also indicates the possible dissociation of the morphine analgesic effect from its tolerance-development mechanism.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2003.06.007