Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells

Adult neurogenesis from neural stem/progenitor cells occurs in discrete regions of the central nervous system of all mammals, but the mechanisms regulating endogenous neurogenesis are poorly understood. Advances in understanding the neurogenesis depend on knowing their intrinsic properties and respo...

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Bibliographic Details
Published in:Molecular and cellular neuroscience 2006-03, Vol.31 (3), p.560-573
Main Authors: Ray, Jasodhara, Gage, Fred H.
Format: Article
Language:English
Subjects:
Adult mouse and rat brain-derived neural stem/progenitor cells
Animals
Brain - cytology
Brain - embryology
Brain - growth & development
Cell Adhesion - drug effects
Cell Adhesion - physiology
Cell Differentiation - drug effects
Cell Differentiation - physiology
Cell Proliferation - drug effects
Cells, Cultured
Colforsin - pharmacology
Culture Media - pharmacology
EGF
Epidermal Growth Factor - metabolism
Epidermal Growth Factor - pharmacology
Extracellular Matrix - drug effects
Extracellular Matrix - metabolism
FGF-2
Fibroblast Growth Factor 2 - metabolism
Fibroblast Growth Factor 2 - pharmacology
Forskolin
Growth Substances - pharmacology
Heparan Sulfate Proteoglycans - metabolism
Heparan Sulfate Proteoglycans - pharmacology
Heparin - pharmacology
Heparin/heparan sulfate proteoglycans
Mice
Mice, Inbred C57BL
Mitogens - pharmacology
Neurogenesis
Neurons - cytology
Neurons - physiology
Rats
Rats, Inbred F344
Retinoic acid
Species Specificity
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - physiology
Tretinoin - metabolism
Tretinoin - pharmacology
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Summary:Adult neurogenesis from neural stem/progenitor cells occurs in discrete regions of the central nervous system of all mammals, but the mechanisms regulating endogenous neurogenesis are poorly understood. Advances in understanding the neurogenesis depend on knowing their intrinsic properties and responses to environmental signals that control their behavior. Before these issues can be addressed, it is necessary to know whether there are significant species-specific differences in the properties of the stem/progenitor cells derived from CNS of two commonly studied model systems, mouse and rat. We found major differences between rat and mouse stem/progenitor cell proliferation in response to various substrates, mitogenic growth factors and heparin and to the influence of differentiation factors on generation of neurons and glia. Thus, extrapolation of cell properties from one species to another based on studies of these cells should be made with caution.
ISSN:1044-7431
1095-9327
DOI:10.1016/j.mcn.2005.11.010