Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males

Resistance exercise has recently been shown to improve whole-body insulin sensitivity in healthy males. Whether this is accompanied by an exercise-induced decline in skeletal muscle glycogen and/or lipid content remains to be established. In the present study, we determined fibre-type-specific chang...

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Bibliographic Details
Published in:European journal of applied physiology 2006-03, Vol.96 (5), p.525-534
Main Authors: Koopman, René, Manders, Ralph J F, Jonkers, Richard A M, Hul, Gabby B J, Kuipers, Harm, van Loon, Luc J C
Format: Article
Language:English
Subjects:
Adult
Biopsy
Blood Glucose
Exercise
Exercise - physiology
Fatty Acids, Nonesterified - blood
Glycogen - metabolism
Humans
Lactic Acid - blood
Male
Muscle Cells - cytology
Muscle Cells - metabolism
Muscle, Skeletal - cytology
Muscle, Skeletal - metabolism
Muscular system
Oxidative Phosphorylation
Physical Fitness - physiology
Triglycerides - metabolism
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Summary:Resistance exercise has recently been shown to improve whole-body insulin sensitivity in healthy males. Whether this is accompanied by an exercise-induced decline in skeletal muscle glycogen and/or lipid content remains to be established. In the present study, we determined fibre-type-specific changes in skeletal muscle substrate content following a single resistance exercise session. After an overnight fast, eight untrained healthy lean males participated in a approximately 45 min resistance exercise session. Muscle biopsies were collected before, following cessation of exercise, and after 30 and 120 min of post-exercise recovery. Subjects remained fasted throughout the test. Conventional light and (immuno)fluorescence microscopy were applied to assess fibre-type-specific changes in intramyocellular triacylglycerol (IMTG) and glycogen content. A significant 27+/-7% net decline in IMTG content was observed in the type I muscle fibres (P
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-005-0118-0