Changes in vascularity and blood volume as a result of photodynamic therapy can be assessed with power Doppler ultrasonography

Background and Objectives One principal mechanism of photodynamic therapy (PDT) in tumors is destruction of tumor‐associated vasculature. In the present study, the vascular effects of PDT in tumors were investigated with power Doppler ultrasonography. Materials and Methods Seven cutaneous squamous c...

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Published in:Lasers in surgery and medicine 2006-03, Vol.38 (3), p.229-234
Main Authors: Ohlerth, Stefanie, Laluhová, Dagmar, Buchholz, Julia, Roos, Malgorzata, Walt, Heinrich, Kaser-Hotz, Barbara
Format: Article
Language:English
Subjects:
Animals
Blood Volume
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - physiopathology
cat
Cats
Female
Image Processing, Computer-Assisted
Male
Mesoporphyrins - therapeutic use
Neovascularization, Pathologic
Photochemotherapy
Photosensitizing Agents - therapeutic use
Skin - blood supply
Skin Neoplasms - diagnostic imaging
Skin Neoplasms - drug therapy
Skin Neoplasms - physiopathology
Squamous cell carcinoma
Ultrasonography, Doppler
vessels
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Summary:Background and Objectives One principal mechanism of photodynamic therapy (PDT) in tumors is destruction of tumor‐associated vasculature. In the present study, the vascular effects of PDT in tumors were investigated with power Doppler ultrasonography. Materials and Methods Seven cutaneous squamous cell carcinomas in cats were treated. Tumors were examined via power Doppler ultrasonography before, 5 minutes, 1 hour, and 24 hours after PDT. Images were digitized for computer‐aided assessment of vascularity and blood volume. Results Mean baseline tumor vascularity and blood volume were moderate. During PDT, a significant decrease in vascularity and blood volume was noted. Lowest values were found 24 hours after PDT. Conclusions Power Doppler ultrasonography represents a non‐invasive modality to successfully monitor the vascular effects and thus, treatment efficacy, of PDT. Lasers Surg. Med. 38:229–234, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.20282