Mucosal vaccination with an attenuated maedi–visna virus clone

Four sheep were infected intratracheally with an attenuated molecular clone of maedi–visna virus (MVV). All four became infected. Ten months later these sheep were challenged intratracheally with a genetically similar but pathogenic clone of MVV. Four unvaccinated sheep were infected simultaneously....

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Bibliographic Details
Published in:Vaccine 2005-05, Vol.23 (24), p.3223-3228
Main Authors: Pétursson, Gudmundur, Matthíasdóttir, Sigrídur, Svansson, Vilhjálmur, Andrésdóttir, Valgerdur, Georgsson, Gudmundur, Martin, Agnes H., Agnarsdóttir, Gudrún, Gísladóttir, Eygló, Árnadóttir, Steinunn, Högnadóttir, Svava, Jónsson, Stefán Ragnar, Andrésson, Ólafur S., Torsteinsdóttir, Sigurbjörg
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - analysis
Antibodies, Viral - biosynthesis
Antigens
Applied microbiology
Attenuated virus
Biological and medical sciences
Cloning
Cloning, Molecular
Enzyme-Linked Immunosorbent Assay
Experiments
Female
Fundamental and applied biological sciences. Psychology
Immunity, Mucosal - immunology
In Situ Hybridization
Infections
Maedi–visna
Microbiology
Miscellaneous
Mucosal vaccination
Pathology
Sheep
Superinfection - prevention & control
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - immunology
Viral Load
Viral Vaccines - immunology
Virology
Visna - immunology
Visna - prevention & control
Visna - virology
Visna-maedi virus - immunology
Visna-maedi virus - isolation & purification
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Description
Summary:Four sheep were infected intratracheally with an attenuated molecular clone of maedi–visna virus (MVV). All four became infected. Ten months later these sheep were challenged intratracheally with a genetically similar but pathogenic clone of MVV. Four unvaccinated sheep were infected simultaneously. All sheep became infected by the challenge virus. The vaccinated sheep were not protected against superinfection with the challenge clone. However, virus was isolated more frequently from the blood of the unvaccinated controls than of the vaccinated animals and ten times more frequently from lungs of unvaccinated sheep than from lungs of vaccinated sheep at sacrifice, indicating partial protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.11.074