Angiotensin converting enzyme inhibitor use is associated with higher bone mineral density in elderly Chinese

• Published in: Bone (New York, N.Y.) N.Y.), 2006-04, Vol.38 (4), p.584-588
• Main Authors: Lynn, H., Kwok, T., Wong, S.Y.S., Woo, J., Leung, P.C.
• Format: Article
• Language: English
• Subjects: ACE inhibitor; Aged; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - therapeutic use; Biological and medical sciences; Bone Density; Bone mineral density; Chinese; Fundamental and applied biological sciences. Psychology; Hong Kong; Humans; Interviews as Topic; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Osteoarticular system. Muscles; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Surveys and Questionnaires; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2005.09.011

Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men ( n = 1958) and women ( n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 years and above, and were recruited using a combination of private solicitation and public advertising from community centers, housing estates, and the general community in Hong Kong. Demographic, medical, and lifestyle information was obtained from face to face interviews using standardized questionnaire, and physical examination measurements included anthropometry, tibial, and brachial systolic blood pressures, femoral neck, total hip, and lumbar spine BMD. In multiple regression analyses, after adjusting for age, weight, height, thiazide, beta-blocker, calcium channel blocker, statin, corticosteroid, and calcium supplement use, history of diabetes, heart disease, peripheral vascular disease, cigarette smoking, alcohol intake, and physical activity level, ACEI use was associated with higher femoral neck BMD (+0.015 g/cm 2, P = 0.035) in women, and higher femoral neck (+0.015 g/cm 2, P = 0.017), total hip (+0.016 g/cm 2, P = 0.021), and lumbar spine (+0.043 g/cm 2, P