Safety and Efficacy of Nonanimal Stabilized Hyaluronic Acid for Improvement of Mouth Corners

BACKGROUNDEsthetic concern with downturned mouth corners (“mouth frown”) is increasing in the aging baby-boomer generation. A new technique to offer structural support using the recently approved filler nonanimal stabilized hyaluronic acid (NASHA; Restylane, Q-med Inc., Uppsala, Sweden) is described...

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Bibliographic Details
Published in:Dermatologic surgery 2005-03, Vol.31 (3), p.276-280
Main Authors: Carruthers, Jean, Klein, Arnold W, Carruthers, Alastair, Glogau, Richard G, Canfield, Douglas
Format: Article
Language:English
Subjects:
Adult
Biocompatible Materials - administration & dosage
Biological and medical sciences
Cosmetic Techniques
Dermatology
Esthetics
Female
General aspects
Humans
Hyaluronic Acid - administration & dosage
Hyaluronic Acid - analogs & derivatives
Injections, Intradermal
Lip
Medical sciences
Middle Aged
Patient Satisfaction
Prospective Studies
Skin Aging - drug effects
Skin plastic surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Time Factors
Treatment Outcome
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Summary:BACKGROUNDEsthetic concern with downturned mouth corners (“mouth frown”) is increasing in the aging baby-boomer generation. A new technique to offer structural support using the recently approved filler nonanimal stabilized hyaluronic acid (NASHA; Restylane, Q-med Inc., Uppsala, Sweden) is described. METHODFifteen women with prominent downturned mouth corners met the inclusion criteria for the study. All were photographed before and at 1 week, 3 months, 4.5 months, and 6 months after treatment using a standardized clinical photographic system. NASHA was injected using a standardized technique with nerve block anesthesia to ensure patient comfort. RESULTSAll 15 women noted swelling, redness, and some local discomfort for several days after the injection. All noted an improvement in the downward angulation of their mouth corners at the first post-treatment visit, with at least partial improvement maintained through the 6-month post-treatment follow-up visit. CONCLUSIONSNASHA injection to support the age-related downturn of lateral lip corners was effective, safe, and well tolerated in a small prospective study of middle-aged female subjects. Esthetic satisfaction was greatest in the first 3 months post-treatment, but 40% of subjects still noted improvement at the 6-month follow-up visit.
ISSN:1076-0512
1524-4725
DOI:10.1097/00042728-200503000-00004