Affective flattening and alogia associate with the familial form of schizophrenia

Family history of schizophrenia has been associated with negative symptoms in the clinical picture. Our aim was to examine the signs and symptoms of schizophrenia in a genetically homogeneous isolate and a nationwide multiplex family sample, and to investigate the symptom dimensions and their associ...

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Bibliographic Details
Published in:Psychiatry research 2006-02, Vol.141 (2), p.161-172
Main Authors: Arajärvi, Ritva, Varilo, Teppo, Haukka, Jari, Suvisaari, Jaana, Suokas, Jaana, Juvonen, Hannu, Muhonen, Maria, Suominen, Kirsi, Hintikka, Jukka, Schreck, Marjut, Tuulio-Henriksson, Annamari, Partonen, Timo, Lönnqvist, Jouko
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affect
Aphasia - diagnosis
Aphasia - etiology
Biological and medical sciences
Diagnostic and Statistical Manual of Mental Disorders
Factor analysis
Factor Analysis, Statistical
Female
Genetics
Humans
Male
Medical sciences
Middle Aged
Negative symptoms
Pedigree
Positive symptoms
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Registries
Schizophrenia
Schizophrenia - complications
Schizophrenia - genetics
Severity of Illness Index
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Summary:Family history of schizophrenia has been associated with negative symptoms in the clinical picture. Our aim was to examine the signs and symptoms of schizophrenia in a genetically homogeneous isolate and a nationwide multiplex family sample, and to investigate the symptom dimensions and their association with the degree of familial loading for psychotic disorders and with consanguinity. For factor analysis of the Scales for the Assessment of Negative and Positive Symptoms, we included 290 patients with a DSM-IV diagnosis of schizophrenia: 63 multiplex family and 133 singleton patients from the isolate, and 94 nationwide multiplex family patients. The factor analysis yielded four factors. There was a significant difference between the multiplex and singleton patients, the former having more severe affective flattening and alogia. Further, the patients in isolate groups had fewer delusions and hallucinations compared with the whole country multiplex patients regardless of their familial loading for schizophrenia. This may be related to genetic homogeneity in the isolate. We conclude that patients with first-degree relatives with psychotic disorder have more severe negative symptoms.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2005.08.008