Effect of electrical polarization of hydroxyapatite ceramics on new bone formation

Large surface charges can be induced on hydroxyapatite (HAp) ceramics by proton transport polarization, but this does not affect beta-tricalcium phosphate (TCP) because of its low polarizability. We wished to examine differences in osteogenic cell activity and new bone growth between positively or n...

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Bibliographic Details
Published in:Calcified tissue international 2006-03, Vol.78 (3), p.133-142
Main Authors: Itoh, S, Nakamura, S, Kobayashi, T, Shinomiya, K, Yamashita, K
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Bone Substitutes
Ceramics - chemistry
Durapatite - chemistry
Electric Conductivity
Implants, Experimental
Male
Osteogenesis
Prosthesis Implantation
Rats
Rats, Sprague-Dawley
Skull - surgery
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Summary:Large surface charges can be induced on hydroxyapatite (HAp) ceramics by proton transport polarization, but this does not affect beta-tricalcium phosphate (TCP) because of its low polarizability. We wished to examine differences in osteogenic cell activity and new bone growth between positively or negatively surface-charged HAp and HAp/TCP plates using a calvarial bone defect model. In the first group of rats, test pieces were placed with their positively charged surfaces face down on the dura mater. In the second group, test pieces were placed with their negatively charged surfaces face down on the dura mater. A third group received noncharged test pieces. Histological examination, including enzymatic staining for osteoblasts and osteoclasts, was carried out. While no bone formation was observed at the pericranium, direct bone formation on the cranial bone debris and new bone growth expanded from the margins of the sites of injury to bridge across both the positively and negatively charged surfaces of HAp and HAp/TCP plates occurred. Electrical polarization of implanted plates, including positive charge, led to enhanced osteoblast activity, though decreased osteoclast activity was seen on the positively charged plate surface. Thus, polarization of HAp ceramics may modulate new bone formation and resorption.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-005-0213-6