Transcription attenuation: a highly conserved regulatory strategy used by bacteria

We employed computational analyses to assess the conservation of sequence elements that are believed to be essential for the various transcription-attenuation (termination) mechanisms that are used to regulate expression of families of orthologous genes in bacteria. We searched the upstream sequence...

Full description

Saved in:
Bibliographic Details
Published in:Trends in genetics 2005-05, Vol.21 (5), p.260-264
Main Authors: Merino, Enrique, Yanofsky, Charles
Format: Article
Language:English
Subjects:
Bacteria - genetics
Biological and medical sciences
Conserved Sequence
Electron Transport Complex IV - biosynthesis
Electron Transport Complex IV - chemistry
Electron Transport Complex IV - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gene Expression Regulation, Bacterial
Genes
Genetics of eukaryotes. Biological and molecular evolution
Mitochondria - metabolism
Molecular and cellular biology
Transcription, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We employed computational analyses to assess the conservation of sequence elements that are believed to be essential for the various transcription-attenuation (termination) mechanisms that are used to regulate expression of families of orthologous genes in bacteria. We searched the upstream sequence of every predicted transcription unit for a transcription attenuator. These were then clustered by the orthology relationships of the nearby structural genes. Many gene families regulated by transcription attenuation were found to be adjacent to a regulatory region that had a binding site for a specific protein, tRNA or small metabolite. Using our methodology, we predict that at least 80 different clusters of orthologous groups (COGs) are significantly regulated by transcription attenuation.
ISSN:0168-9525
DOI:10.1016/j.tig.2005.03.002