Assessment of malignancy in gliomas by 3T 1H MR spectroscopy

The purpose of this study was to assess clinical 1H MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high-field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumor (i.e., gliomas) was employed to eva...

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Bibliographic Details
Published in:Clinical imaging 2005, Vol.29 (1), p.10-15
Main Authors: Jeun, Sin-Soo, Kim, Moon-Chan, Kim, Bum-Soo, Lee, Jae-Mun, Chung, Sung-Taek, Oh, Chang-Hyun, Lee, Soo-Yeol, Choe, Bo-Young
Format: Article
Language:English
Subjects:
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Biological and medical sciences
Brain - pathology
Brain Neoplasms - chemistry
Brain Neoplasms - diagnosis
Brain tumors
Case-Control Studies
Choline - metabolism
Female
Glioma - chemistry
Glioma - diagnosis
Gliomas
Humans
Lactic Acid - metabolism
Magnetic Resonance Spectroscopy
Male
Malignancy
Medical sciences
Middle Aged
Neurology
Phosphocreatine - metabolism
Tumors of the nervous system. Phacomatoses
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Summary:The purpose of this study was to assess clinical 1H MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high-field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumor (i.e., gliomas) was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantitated as a relative ratio. The variation of metabolite measurements of the designated region in 10 normal volunteers was less than 10%. Normal ranges of NAA/Cr and Cho/Cr ratios were 1.67±018 and 1.16±0.15, respectively. NAA/Cr ratio of gliomas was significantly lower than that of the normal tissues ( P=.005), but Cho/Cr ratio of gliomas was significantly higher ( P=.001). Cho/Cr ratio of high-grade gliomas was significantly higher than that of low-grade gliomas. The present study demonstrated that the neuronal degradation or loss was observed in all gliomas. Higher-grade glioma was correlated with higher Cho/Cr ratio, indicating a significant dependence of Cho levels on malignancy of gliomas. Our results suggest that clinical 1H MR spectroscopy could be useful to predict tumor malignancy.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2004.03.004