Increased Levels of Soluble Adhesion Molecules E-Selectin and P-Selectin in Patients with Cardiac Syndrome X

The role of endothelial dysfunction and platelet activation in patients with cardiac syndrome X is controversial. The aim of this study was to investigate the plasma levels of circulating E- and P-selectin molecules in patients with syndrome X. The study included 21 patients with cardiac syndrome X...

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Bibliographic Details
Published in:Angiology 2005-05, Vol.56 (3), p.273-277
Main Authors: Senen, Kubilay, Ileri, Mehmet, Alper, Aysin, Yetkin, Funda, Atak, Ramazan, Hisar, Ismet, Yetkin, Ertan, Turhan, Hasan, Bardakçı, Haşmet, Demirkan, Deniz
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood and lymphatic vessels
Blood coagulation. Blood cells
Cardiology. Vascular system
Coronary Disease - blood
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
E-Selectin - blood
Female
Fundamental and applied biological sciences. Psychology
General and cellular metabolism. Vitamins
Humans
Male
Medical sciences
Microvascular Angina - blood
Middle Aged
Molecular and cellular biology
P-Selectin - blood
Pharmacology. Drug treatments
Platelet
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Summary:The role of endothelial dysfunction and platelet activation in patients with cardiac syndrome X is controversial. The aim of this study was to investigate the plasma levels of circulating E- and P-selectin molecules in patients with syndrome X. The study included 21 patients with cardiac syndrome X (11 men and 10 women, mean age = 56 ±5 years) and 20 patients with significant coronary artery disease who had stable angina pectoris (11 men and 9 women, mean age = 60 ±8 years). Twenty-two age- and sex-matched subjects (12 men and 10 women, mean age = 58 ±8 years) undergoing diagnosis of atypical chest pain in whom coronary arteries were found normal and exercise test had no signs of ischemia served as the control group. Syndrome X was defined as presence of typical chest pain on exertion or at rest with positive exercise test and angiographically normal epicardial coronary arteries with no evidence of coronary spasm after intracoronary infusion of ergonovine maleate. The mean plasma concentrations of P-selectin were significantly elevated both in patients with coronary artery disease and syndrome X as compared with control subjects (49.15 ±7.47 and 42.80 ±8.93 vs 22.63 ±6.47 ng/mL, p
ISSN:0003-3197
1940-1574
DOI:10.1177/000331970505600306