An evaluation of longitudinal neurocognitive performance among middle-aged and older schizophrenia patients: Use of mixed-model analyses

The purpose of this study was to evaluate the trajectory of neuropsychological performance among middle-aged and older patients with schizophrenia using hierarchical linear modeling (HLM). Using the Mattis Dementia Rating Scale (DRS), we assessed cognitive performance of 143 schizophrenia outpatient...

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Bibliographic Details
Published in:Schizophrenia research 2006-04, Vol.83 (2), p.215-223
Main Authors: Nayak Savla, Gauri, Moore, David J., Roesch, Scott C., Heaton, Robert K., Jeste, Dilip V., Palmer, Barton W.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age Factors
Aged
Aged, 80 and over
Aging
Biological and medical sciences
Cognition
Cognition - physiology
Female
Humans
Linear Models
Longitudinal
Longitudinal Studies
Male
Medical sciences
Mental Status Schedule
Middle Aged
Neuropsychological Tests - statistics & numerical data
Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reference Values
Schizophrenia
Schizophrenia - physiopathology
Time Factors
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Summary:The purpose of this study was to evaluate the trajectory of neuropsychological performance among middle-aged and older patients with schizophrenia using hierarchical linear modeling (HLM). Using the Mattis Dementia Rating Scale (DRS), we assessed cognitive performance of 143 schizophrenia outpatients (Mean age = 53.1 years, SD = 8.8) and 66 healthy comparison subjects (Mean age = 61.8 years, SD = 8.8). All participants had DRS data from two or more testing sessions with average intervals between sessions being 15 months (range = 6–55). Using HLM, we found cognitive performance to be stable over time in both schizophrenia patients and healthy comparison subjects. Age, gender, ethnicity, and education did not affect trajectories. We also analyzed the data using more traditional statistical approaches to longitudinal data and found similar results. In sum, we found cognitive impairment to be stable over time among outpatients with schizophrenia, regardless of the statistical methodology used to analyze longitudinal data.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2005.12.851