Potency requirements of rabies vaccines administered intradermally using the Thai Red Cross regimen: investigation of the immunogenicity of serially diluted purified chick embryo cell rabies vaccine

To determine the minimum vaccine potency per intradermal dose required to elicit an adequate immune response using the Thai Red Cross (TRC) regimen (2-2-2-0-1-1), healthy volunteers received 0.1 mL volumes of PCECV containing decreasing amounts of antigen. Subjects also received HRIG to evaluate pot...

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Bibliographic Details
Published in:Vaccine 2005-06, Vol.23 (30), p.3902-3907
Main Authors: Beran, Jiri, Honegr, Karel, Banzhoff, Angelika, Malerczyk, Claudius
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antibodies, Viral - analysis
Antibodies, Viral - biosynthesis
Antigens
Applied microbiology
Biological and medical sciences
Biological Assay
Cell culture
Cercopithecus aethiops
Chick Embryo
Developing countries
Fundamental and applied biological sciences. Psychology
Hospitals
Humans
Immune response
Immune system
Immunogenicity
Immunoglobulins - analysis
Injections, Intradermal
Intradermal
LDCs
Microbiology
Miscellaneous
PCECV
Potency
Rabies
Rabies - immunology
Rabies - prevention & control
Rabies Vaccines - administration & dosage
Rabies Vaccines - adverse effects
Rabies Vaccines - immunology
Thai Red Cross regimen
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
Vero Cells
Virology
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Description
Summary:To determine the minimum vaccine potency per intradermal dose required to elicit an adequate immune response using the Thai Red Cross (TRC) regimen (2-2-2-0-1-1), healthy volunteers received 0.1 mL volumes of PCECV containing decreasing amounts of antigen. Subjects also received HRIG to evaluate potential interference with antibody production. Results indicated that when each 0.1 mL intradermal dose of PCECV contained antigen corresponding to 0.32 IU per intramuscular dose, every subject had titers above 0.5 IU/mL by day 14. These results confirm that the current World Health Organization (WHO) recommendations for vaccine potency (2.5 IU per intramuscular dose) are sufficient for use in the Thai Red Cross intradermal regimen.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.03.007