The role of actin bundling protein fascin in the progression of ovarian neoplasms

The aim of the study was to investigate the role of fascin in tumor progression and to investigate the role of fascin on endothelial cell migration and angiogenesis in ovarian neoplasms. In the study, 94 malign epithelial ovarian neoplasms, 13 borderline epithelial ovarian neoplasms, 25 serous and m...

Full description

Saved in:
Bibliographic Details
Published in:European journal of gynaecological oncology 2006, Vol.27 (2), p.171-176
Main Authors: Kabukcuoglu, S, Oner, U, Ozalp, S S, Bildirici, K, Yalcin, O T, Colak, E
Format: Article
Language:English
Subjects:
Actins - metabolism
Antibodies, Monoclonal
Carrier Proteins - metabolism
Cell-Matrix Junctions - pathology
Cystadenoma, Mucinous - metabolism
Cystadenoma, Mucinous - pathology
Cystadenoma, Mucinous - surgery
Disease Progression
Female
Humans
Immunohistochemistry
Microfilament Proteins - metabolism
Neoplasms, Glandular and Epithelial
Neovascularization, Pathologic - pathology
Ovarian Neoplasms - blood
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Up-Regulation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the study was to investigate the role of fascin in tumor progression and to investigate the role of fascin on endothelial cell migration and angiogenesis in ovarian neoplasms. In the study, 94 malign epithelial ovarian neoplasms, 13 borderline epithelial ovarian neoplasms, 25 serous and mucinous cystadenomas and four normal ovarian tissues were examined by means of immunohistochemistry, using monoclonal antihuman fascin antibody, clone IM20. Total stromal fascin score in cases of borderline and malign epithelial ovarian tumors was significantly higher compared to normal ovaries and benign epithelial ovarian tumors (.000, p < 0.001). There was no statistically significant difference in terms of total epithelial fascin scores of samples between groups (.080, p > 0.05). Presence of vascular invasion (.000, p < 0.001), psammomatous calcifications (.001, p = 0.001), and lymphocytic infiltration (.000, p < 0.001) were significantly higher in malign neoplasms. There was no significant difference in terms of mean microvessel count and homogeneous or heterogeneous fascin expression of microvessels between the benign and malign groups (respectively p = .228 and p = .143). This study suggests that up-regulation of fascin in tumoral tissue may promote invasion of ovarian carcinoma by cell-matrix adhesion.
ISSN:0392-2936