Array-based Genomic Analysis of Screen-detected Gleason Score 6 and 7 Prostatic Adenocarcinomas

Background: Prostate cancer is known for its heterogeneous histological appearance. It is currently not clear whether this histological heterogeneity is also reflected in the genomic composition of a tumor. Materials and Methods: The cancer DNA's were retrieved from the European Randomized Stud...

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Bibliographic Details
Published in:Anticancer research 2006-03, Vol.26 (2A), p.1193-1200
Main Authors: POSTMA, Renske, VAN MARION, Ronald, VAN DUIN, Mark, VISSERS, Kees J, WINK, Josiane C, SCHRÖDER, Fritz H, TANKE, Hans J, SILUHAI, Karoly, VAN DER KWAST, Theo H, VAN DEKKEN, Herman
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Biological and medical sciences
Chromosome Aberrations
Humans
Male
Mass Screening
Medical sciences
Middle Aged
Neoplasm Staging
Nephrology. Urinary tract diseases
Nucleic Acid Hybridization - methods
Oligonucleotide Array Sequence Analysis - methods
Prostatectomy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:Background: Prostate cancer is known for its heterogeneous histological appearance. It is currently not clear whether this histological heterogeneity is also reflected in the genomic composition of a tumor. Materials and Methods: The cancer DNA's were retrieved from the European Randomized Study of Screening for Prostate Cancer section Rotterdam (ERSPC). Tumors with volumes 1.0-1.5 ml and a Gleason score of 3+3 or 3+4 were selected. Comparative genomic hybridization with a 3500-element BAC array was used to detect differences in the genetic content of Gleason patterns 3 and 4. Results: A total of 1155 gains and 583 losses were discriminated in 10 G3 areas; 768 gains and 497 losses were detected in 7 G4 regions. Frequent losses included chromosome arms 6q, 8p and 13q, while frequent gains were seen on 7q and 8q. There were no significant differences between Gleason patterns 3 and 4, or between Gleason grades within one cancer. Conclusion: Histological heterogeneity, defined by Gleason grades 3 and 4, does not have a genomic counterpart. Furthermore, these asymptomatic screen-detected prostate carcinomas have genetic signatures comparable with those commonly seen in symptomatic cancers.
ISSN:0250-7005
1791-7530