The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure

Patients with mild‐moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function...

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Bibliographic Details
Published in:European journal of heart failure 2005-06, Vol.7 (4), p.461-467
Main Author: Reyes, Ariel J.
Format: Article
Language:English
Subjects:
Allopurinol - pharmacology
Antioxidant capacity
Diuretics
Diuretics - pharmacology
Free Radical Scavengers - pharmacology
Heart failure
Heart Failure - blood
Heart Failure - physiopathology
Humans
Kidney - metabolism
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Uric acid
Uric Acid - blood
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Summary:Patients with mild‐moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels worsening cardiac function also contributes to elevated serum UA in patients with advanced CHF. However, UA production also appears to be augmented in CHF. Because UA scavenges various reactive oxygen species, diuretic‐induced elevations in serum UA could be beneficial in patients with CHF. This concept is supported by the superior performance of antihypertensive therapy with diuretics in preventing heart failure. The present hypothesis may be tested by examining the effects of add‐on treatment with a thiazide‐type diuretic on morbidity and mortality, or surrogate variables, in asymptomatic patients with left ventricular dysfunction but without fluid retention.
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2004.03.020