Body Fat at Birth and Cord Blood Levels of Insulin, Adiponectin, Leptin, and Insulin-like Growth Factor-I in Small-for-Gestational-Age Infants

Low birthweight has been associated with an increased risk of obesity, insulin resistance, and diabetes in adulthood. The aim of this study was to evaluate IGF-I, adiponectin, insulin levels, and body fat in small-for-gestational-age (SGA) infants at birth. We performed a transverse comparative stud...

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Bibliographic Details
Published in:Archives of medical research 2006-05, Vol.37 (4), p.490-494
Main Authors: Martínez-Cordero, Claudia, Amador-Licona, Norma, Guízar-Mendoza, Juan Manuel, Hernández-Méndez, Javier, Ruelas-Orozco, Guillermo
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Adiposity - physiology
Adult
Birth Weight
Body fat
Fats
Female
Fetal Blood - metabolism
Gestational Age
Humans
IGF-I
Infant, Low Birth Weight - blood
Infant, Low Birth Weight - physiology
Infant, Newborn
Insulin
Insulin - blood
Insulin-Like Growth Factor I - metabolism
Leptin
Leptin - blood
Small-for-gestational age
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Summary:Low birthweight has been associated with an increased risk of obesity, insulin resistance, and diabetes in adulthood. The aim of this study was to evaluate IGF-I, adiponectin, insulin levels, and body fat in small-for-gestational-age (SGA) infants at birth. We performed a transverse comparative study in SGA and appropriate-for-gestational-age (AGA) infants. The study was conducted at the Hospital of Gynecology and Obstetrics in Leon, Mexico. Weight, length, and percent of body fat were evaluated during the first 48 h of birth. Glucose, insulin, leptin, adiponectin, and IGF-I levels in cord blood were measured. We studied 100 infants (50 SGA and 50 AGA). A history of diabetes in a second-degree relative was higher in SGA infants than in AGA infants (48.0 vs. 30.0%, respectively; p = 0.03). Glucose, adiponectin, insulin and IGF-I levels were similar between the groups. Leptin levels and percentage of body fat were lower in SGA than AGA (15.3 vs. 23.4 ng/mL; p = 0.003, 11.1 vs. 12.7%; p
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2005.11.004