Simultaneous very low dose mifepristone and vaginal misoprostol for medical abortion

This pilot study was designed to evaluate the outcome of medical abortion following simultaneous mifepristone (100 mg) and misoprostol (800 μg). Enrollees had gestational ages up to 56 days and desired a medical abortion. They received 100 mg of mifepristone orally and 800 μg of misoprostol vaginall...

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Bibliographic Details
Published in:Contraception (Stoneham) 2006-05, Vol.73 (5), p.525-527
Main Authors: Kapp, Nathalie, Borgatta, Lynn, Ellis, Sacheen Carr, Stubblefield, Phillip
Format: Article
Language:English
Subjects:
Abortifacient Agents, Nonsteroidal - administration & dosage
Abortifacient Agents, Steroidal - administration & dosage
Abortion, Induced - methods
Administration, Intravaginal
Administration, Oral
Adolescent
Adult
Biological and medical sciences
Birth control
Drug Administration Schedule
Female
Genital system. Reproduction
Gynecology. Andrology. Obstetrics
Humans
Induced abortion. Therapeutic abortion
Medical abortion
Medical sciences
Mifepristone
Mifepristone - administration & dosage
Misoprostol
Misoprostol - administration & dosage
Pharmacology. Drug treatments
Pilot Projects
Pregnancy
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Summary:This pilot study was designed to evaluate the outcome of medical abortion following simultaneous mifepristone (100 mg) and misoprostol (800 μg). Enrollees had gestational ages up to 56 days and desired a medical abortion. They received 100 mg of mifepristone orally and 800 μg of misoprostol vaginally. Follow-up examination occurred in 2–7 days. A phone call 3 weeks later assessed symptoms and acceptability. A 95% success rate, as seen in higher dose studies, gives a 95% confidence interval of 88–100% for 40 subjects. Forty women were enrolled; 39 women had follow-up visits. Completed medical abortion was confirmed for 35 (90%) of 39 women. Four women had uterine aspiration. Two patients required repeat misoprostol. Median time from medication to abortion was 7 h. Most women (92%) strongly preferred taking all medications in the clinic. The simultaneous administration of vaginal misoprostol with 100 mg of oral mifepristone had the outcome of completed abortion within the predicted confidence interval. In addition, simultaneous dosing was highly acceptable.
ISSN:0010-7824
1879-0518
DOI:10.1016/j.contraception.2005.12.011