Hypocretins: Waking, Arousal, or Action?

The role of hypocretin (orexin) neurotransmission in waking and arousal, though of intense interest, is poorly understood. In this issue of Neuron, Mileykovskiy et al., 2005 demonstrate that, in general, hypocretin neurons are minimally active during both sleep and quiet waking. In contrast, these n...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2005-06, Vol.46 (5), p.696-698
Main Authors: Berridge, Craig W., España, Rodrigo A.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Arousal - physiology
Behavior
Brain
Food
Gene expression
Humans
Hypotheses
Neurons
Neurons - metabolism
Neurons - physiology
Neurosciences
Orexin Receptors
Receptors, G-Protein-Coupled
Receptors, Neuropeptide - metabolism
Receptors, Neuropeptide - physiology
Rodents
Studies
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Summary:The role of hypocretin (orexin) neurotransmission in waking and arousal, though of intense interest, is poorly understood. In this issue of Neuron, Mileykovskiy et al., 2005 demonstrate that, in general, hypocretin neurons are minimally active during both sleep and quiet waking. In contrast, these neurons display robust activity during periods of alert and/or active waking.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2005.05.016