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Sweat-testing in preterm and full-term infants less than 6 weeks of age
Our objective was to examine the characteristics of preterm and full‐term infants ≤6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and corresponding sweat chloride concentrations. A retrospective chart review of 119 sweat tests was performed on 103 preterm a...
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| Published in: | Pediatric pulmonology 2005-07, Vol.40 (1), p.64-67 |
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| Language: | English |
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| container_end_page | 67 |
| container_issue | 1 |
| container_start_page | 64 |
| container_title | Pediatric pulmonology |
| container_volume | 40 |
| creator | Eng, Warren LeGrys, Vicky A. Schechter, Michael S. Laughon, Matthew M. Barker, Pierre M. |
| description | Our objective was to examine the characteristics of preterm and full‐term infants ≤6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and corresponding sweat chloride concentrations. A retrospective chart review of 119 sweat tests was performed on 103 preterm and full‐term infants ≤6 weeks of age. Bivariate and multivariate regression analyses were used to determine the predictors of successful sweat testing and characteristics influencing sweat chloride concentrations. Adequate amounts of sweat (≥75 mg) were obtained for analysis in 73.8% of initial attempts in the infant group. The following characteristics were associated with increased odds of obtaining a quantity not sufficient (QNS) for sweat chloride concentration measurement: African‐American race, infant weight |
| doi_str_mv | 10.1002/ppul.20235 |
| format | article |
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A retrospective chart review of 119 sweat tests was performed on 103 preterm and full‐term infants ≤6 weeks of age. Bivariate and multivariate regression analyses were used to determine the predictors of successful sweat testing and characteristics influencing sweat chloride concentrations. Adequate amounts of sweat (≥75 mg) were obtained for analysis in 73.8% of initial attempts in the infant group. The following characteristics were associated with increased odds of obtaining a quantity not sufficient (QNS) for sweat chloride concentration measurement: African‐American race, infant weight <2,000 g, preterm birth, and postmenstrual age (PMA) <36 weeks. With a multivariable logistic model, the only significant predictors were African‐American race (7.3, 2.4–21.7) and PMA <36 weeks (17.9, 4.2–75.9). Sweat chloride concentration in non‐CF individuals is inversely related to both gestational age and age at testing, and this effect is additive in a linear regression model. In conclusion, sweat collection can be reliably performed in infants ≥36 weeks postmenstrual age, >2,000 g, and >3 days postnatal age. Maturational factors have a mild impact on sweat chloride concentration. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.20235</identifier><identifier>PMID: 15880420</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>African Americans ; Biological and medical sciences ; Body Weight ; Chlorides - metabolism ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - metabolism ; Female ; full-term infants ; Gestational Age ; Humans ; Infant ; Infant, Newborn - metabolism ; Infant, Premature - metabolism ; Male ; Mass Screening - methods ; Medical sciences ; Multivariate Analysis ; Pneumology ; preterm infants ; Retrospective Studies ; Risk Factors ; Specimen Handling - methods ; Sweat - metabolism ; sweat chloride ; sweat-testing</subject><ispartof>Pediatric pulmonology, 2005-07, Vol.40 (1), p.64-67</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3955-757bd68cf41d4f3967987f95ce6c0d84a12cee9c2b60802410077814d7ab4a823</citedby><cites>FETCH-LOGICAL-c3955-757bd68cf41d4f3967987f95ce6c0d84a12cee9c2b60802410077814d7ab4a823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16911586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15880420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eng, Warren</creatorcontrib><creatorcontrib>LeGrys, Vicky A.</creatorcontrib><creatorcontrib>Schechter, Michael S.</creatorcontrib><creatorcontrib>Laughon, Matthew M.</creatorcontrib><creatorcontrib>Barker, Pierre M.</creatorcontrib><title>Sweat-testing in preterm and full-term infants less than 6 weeks of age</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>Our objective was to examine the characteristics of preterm and full‐term infants ≤6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and corresponding sweat chloride concentrations. A retrospective chart review of 119 sweat tests was performed on 103 preterm and full‐term infants ≤6 weeks of age. Bivariate and multivariate regression analyses were used to determine the predictors of successful sweat testing and characteristics influencing sweat chloride concentrations. Adequate amounts of sweat (≥75 mg) were obtained for analysis in 73.8% of initial attempts in the infant group. The following characteristics were associated with increased odds of obtaining a quantity not sufficient (QNS) for sweat chloride concentration measurement: African‐American race, infant weight <2,000 g, preterm birth, and postmenstrual age (PMA) <36 weeks. With a multivariable logistic model, the only significant predictors were African‐American race (7.3, 2.4–21.7) and PMA <36 weeks (17.9, 4.2–75.9). Sweat chloride concentration in non‐CF individuals is inversely related to both gestational age and age at testing, and this effect is additive in a linear regression model. In conclusion, sweat collection can be reliably performed in infants ≥36 weeks postmenstrual age, >2,000 g, and >3 days postnatal age. Maturational factors have a mild impact on sweat chloride concentration. © 2005 Wiley‐Liss, Inc.</description><subject>African Americans</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Chlorides - metabolism</subject><subject>Cystic Fibrosis - diagnosis</subject><subject>Cystic Fibrosis - metabolism</subject><subject>Female</subject><subject>full-term infants</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn - metabolism</subject><subject>Infant, Premature - metabolism</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Pneumology</subject><subject>preterm infants</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Specimen Handling - methods</subject><subject>Sweat - metabolism</subject><subject>sweat chloride</subject><subject>sweat-testing</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp90M8vBDEUB_BGCGu5-AOkFw6SoZ3p9MdRhGWzQYI4Nt3OK0N3drQzWf57ZRc3p6bp572-90Voj5JjSkh-0ra9P85JXpRraECJUhlhiq-jgRRlmXHJiy20HeMLIelN0U20RUspCcvJAI3uFmC6rIPY1c0TrhvcBuggzLBpKux677PvW90403QRe4gRd8-mwRwvAF4jnjtsnmAHbTjjI-yuziF6uDi_P7vMJjejq7PTSWYLlYYRpZhWXFrHaMVcobhQUjhVWuCWVJIZmlsAZfMpJ5LkLO0nhKSsEmbKjMyLITpc9m3D_K1PU-tZHS14bxqY91FzIRUjgiZ4tIQ2zGMM4HQb6pkJH5oS_RWb_opNf8eW8P6qaz-dQfVHVzklcLACJlrjXTCNreOf44omy5OjS7eoPXz886W-vX2Y_HyeLWvq2MH7b40Jr2mbQpT68XqkyZiL0aO81OPiE4Q3kms</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Eng, Warren</creator><creator>LeGrys, Vicky A.</creator><creator>Schechter, Michael S.</creator><creator>Laughon, Matthew M.</creator><creator>Barker, Pierre M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>Sweat-testing in preterm and full-term infants less than 6 weeks of age</title><author>Eng, Warren ; LeGrys, Vicky A. ; Schechter, Michael S. ; Laughon, Matthew M. ; Barker, Pierre M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3955-757bd68cf41d4f3967987f95ce6c0d84a12cee9c2b60802410077814d7ab4a823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>African Americans</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Chlorides - metabolism</topic><topic>Cystic Fibrosis - diagnosis</topic><topic>Cystic Fibrosis - metabolism</topic><topic>Female</topic><topic>full-term infants</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn - metabolism</topic><topic>Infant, Premature - metabolism</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Pneumology</topic><topic>preterm infants</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Specimen Handling - methods</topic><topic>Sweat - metabolism</topic><topic>sweat chloride</topic><topic>sweat-testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eng, Warren</creatorcontrib><creatorcontrib>LeGrys, Vicky A.</creatorcontrib><creatorcontrib>Schechter, Michael S.</creatorcontrib><creatorcontrib>Laughon, Matthew M.</creatorcontrib><creatorcontrib>Barker, Pierre M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eng, Warren</au><au>LeGrys, Vicky A.</au><au>Schechter, Michael S.</au><au>Laughon, Matthew M.</au><au>Barker, Pierre M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sweat-testing in preterm and full-term infants less than 6 weeks of age</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2005-07</date><risdate>2005</risdate><volume>40</volume><issue>1</issue><spage>64</spage><epage>67</epage><pages>64-67</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>Our objective was to examine the characteristics of preterm and full‐term infants ≤6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and corresponding sweat chloride concentrations. A retrospective chart review of 119 sweat tests was performed on 103 preterm and full‐term infants ≤6 weeks of age. Bivariate and multivariate regression analyses were used to determine the predictors of successful sweat testing and characteristics influencing sweat chloride concentrations. Adequate amounts of sweat (≥75 mg) were obtained for analysis in 73.8% of initial attempts in the infant group. The following characteristics were associated with increased odds of obtaining a quantity not sufficient (QNS) for sweat chloride concentration measurement: African‐American race, infant weight <2,000 g, preterm birth, and postmenstrual age (PMA) <36 weeks. With a multivariable logistic model, the only significant predictors were African‐American race (7.3, 2.4–21.7) and PMA <36 weeks (17.9, 4.2–75.9). Sweat chloride concentration in non‐CF individuals is inversely related to both gestational age and age at testing, and this effect is additive in a linear regression model. In conclusion, sweat collection can be reliably performed in infants ≥36 weeks postmenstrual age, >2,000 g, and >3 days postnatal age. Maturational factors have a mild impact on sweat chloride concentration. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15880420</pmid><doi>10.1002/ppul.20235</doi><tpages>4</tpages></addata></record> |
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| subjects | African Americans Biological and medical sciences Body Weight Chlorides - metabolism Cystic Fibrosis - diagnosis Cystic Fibrosis - metabolism Female full-term infants Gestational Age Humans Infant Infant, Newborn - metabolism Infant, Premature - metabolism Male Mass Screening - methods Medical sciences Multivariate Analysis Pneumology preterm infants Retrospective Studies Risk Factors Specimen Handling - methods Sweat - metabolism sweat chloride sweat-testing |
| title | Sweat-testing in preterm and full-term infants less than 6 weeks of age |
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