Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity

Many viruses that cause chronic viremic infections, such as human immunodeficiency virus type 1 (HIV-1), mutate extensively to avoid effective control by the host immune system. However, each immune escape mutation probably results in some fitness cost to the virus. The most effective immune respons...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2005-06, Vol.13 (6), p.243-246
Main Authors: Kent, Stephen J., Fernandez, Caroline S., Jane Dale, C., Davenport, Miles P.
Format: Article
Language:English
Subjects:
Animals
Disease Progression
HIV Infections - immunology
HIV Infections - virology
HIV-1 - genetics
HIV-1 - immunology
HIV-1 - physiology
Human immunodeficiency virus 1
Humans
Macaca
Mutation
Simian Acquired Immunodeficiency Syndrome - immunology
Simian Acquired Immunodeficiency Syndrome - virology
Simian Immunodeficiency Virus - genetics
Simian Immunodeficiency Virus - immunology
Simian Immunodeficiency Virus - physiology
T-Lymphocytes, Cytotoxic - immunology
Viral Load
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Summary:Many viruses that cause chronic viremic infections, such as human immunodeficiency virus type 1 (HIV-1), mutate extensively to avoid effective control by the host immune system. However, each immune escape mutation probably results in some fitness cost to the virus. The most effective immune responses might be those that target the regions of the virus where escape mutation inflicts the largest fitness cost to the virus. A virus crippled by immune escape mutations would result in reduced viral load and delayed disease. Such knowledge could be used to rationally design more effective vaccines.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2005.03.011